Mostrar el registro sencillo del ítem
dc.contributor.author
Araya, Roberto
dc.contributor.author
Andino Pavlovsky, Victoria
dc.contributor.author
Yuste, Rafael
dc.contributor.author
Etchenique, Roberto Argentino
dc.date.available
2016-11-07T14:19:46Z
dc.date.issued
2013-05
dc.identifier.citation
Araya, Roberto; Andino Pavlovsky, Victoria; Yuste, Rafael; Etchenique, Roberto Argentino; Two-Photon Optical Interrogation of Individual Dendritic Spines with Caged Dopamine; American Chemical Society; ACS Chemical Neuroscience; 4; 8; 5-2013; 1163-1167
dc.identifier.issn
1948-7193
dc.identifier.uri
http://hdl.handle.net/11336/8018
dc.description.abstract
We introduce a novel caged dopamine compound (RuBi-Dopa) based on ruthenium photochemistry. RuBi-Dopa has a high uncaging efficiency and can be released with visible (blue-green) and IR light in a two-photon regime. We combine two-photon photorelease of RuBi-Dopa with two-photon calcium imaging for an optical imaging and manipulation of dendritic spines in living brain slices, demonstrating that spines can express functional dopamine receptors. This novel compound allows mapping of functional dopamine receptors in living brain tissue with exquisite spatial resolution.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Dopamine
dc.subject
Ruthenium
dc.subject
Two Photon
dc.subject
Caged Compound
dc.subject.classification
Otras Ciencias Químicas
dc.subject.classification
Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Two-Photon Optical Interrogation of Individual Dendritic Spines with Caged Dopamine
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-10-25T19:28:13Z
dc.journal.volume
4
dc.journal.number
8
dc.journal.pagination
1163-1167
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Araya, Roberto. Columbia University; Estados Unidos
dc.description.fil
Fil: Andino Pavlovsky, Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de Los Materiales, Medioambiente y Energía; Argentina. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Yuste, Rafael. Columbia University; Estados Unidos
dc.description.fil
Fil: Etchenique, Roberto Argentino. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de Los Materiales, Medioambiente y Energía; Argentina. Universidad de Buenos Aires; Argentina
dc.journal.title
ACS Chemical Neuroscience
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1021/cn4000692
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/cn4000692
Archivos asociados
Tamaño:
832.2Kb
Formato:
PDF