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Artículo

Differential infectivity of two Trypanosoma cruzi strains in placental cells and tissue

Medina, Lisvaneth; Castillo, Christian; Liempi, Ana; Herbach, Mathias; Cabrera, Gonzalo; Valenzuela, Lucía; Galanti, Norbel; Curto, Maria de Los AngelesIcon ; Schijman, Alejandro GabrielIcon ; Kemmerling, Ulrike
Fecha de publicación: 10/2018
Editorial: Elsevier Science
Revista: Acta Tropica
ISSN: 0001-706X
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular

Resumen

Congenital Chagas disease, caused by Trypanosoma cruzi (T. cruzi), has become epidemiologically relevant. The probability of congenital transmission depends on the maternal and developing fetal/newborn immune responses, placental factors and importantly, the virulence of the parasite. It has been proposed, that different genotypes of T. cruzi and their associated pathogenicity, virulence and tissue tropism may play an important role in congenital infection. Since there is no laboratory or animal model that recapitulates the complexities of vertical transmission in humans, here we studied parasite infectivity in human placental explants (HPE) as well as in the human trophoblast-derived cell line BeWo of the Y(DTU II) and the VD (TcVI) T. cruzi strains; the latter was isolated from a human case of congenital infection. Our results show that the VD strain is more infective and pathogenic than the Y strain, as demonstrated by qPCR and cell counting as well as by histopathological analysis. The present study constitutes the first approach to study the relationship between parasite two parasite strains from different genotypes and the infection efficiency in human placenta.
Palabras clave: Genotypes , Human Placenta , Tropism , Trypanosoma Cruzi
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/79831
DOI: http://dx.doi.org/10.1016/j.actatropica.2018.07.001
URL: https://www.ncbi.nlm.nih.gov/pubmed/30018029
URL: https://www.sciencedirect.com/science/article/pii/S0001706X18300214
Colecciones
Articulos(INGEBI)
Articulos de INST.DE INVEST.EN ING.GENETICA Y BIOL.MOLECULAR "DR. HECTOR N TORRES"
Citación
Medina, Lisvaneth; Castillo, Christian; Liempi, Ana; Herbach, Mathias; Cabrera, Gonzalo; et al.; Differential infectivity of two Trypanosoma cruzi strains in placental cells and tissue; Elsevier Science; Acta Tropica; 186; 10-2018; 35-40
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