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dc.contributor.author
Ramírez, José L.
dc.contributor.author
Mouchantaf, Rania
dc.contributor.author
Kumar, Ujendra
dc.contributor.author
Otero Corchon, Veronica
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dc.contributor.author
Rubinstein, Marcelo
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dc.contributor.author
Low, Malcolm J.
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dc.contributor.author
Patel, Yogesh C.
dc.date.available
2019-07-18T14:03:39Z
dc.date.issued
2002-08
dc.identifier.citation
Ramírez, José L.; Mouchantaf, Rania; Kumar, Ujendra; Otero Corchon, Veronica; Rubinstein, Marcelo; et al.; Brain somatostatin receptors are up-regulated in somatostatin-deficient mice; Endocrine Society; Molecular Endocrinology; 16; 8; 8-2002; 1951-1963
dc.identifier.issn
0888-8809
dc.identifier.uri
http://hdl.handle.net/11336/79786
dc.description.abstract
The peptide somatostatin (SST) is widely synthesized in the brain and periphery and acts through a family of five receptors (SSTR1-5) to exert numerous effects. A gene product related to SST, cortistatin (CST), also interacts with SSTR1-5. Here we have investigated the regulation of SSTR1-5 and of CST in SST knockout (SSTKO) mice. The five SSTRs were quantitated individually by subtype-selective binding analysis, by immunocytochemistry, and by mRNA measurement and showed, in the brain of SSTKO mice, up-regulation of subtypes 1, 2, 4, and 5, and down-regulation of SSTR3. Peripheral tissues displayed both subtype- and tissue-specific changes in SSTR1-5 mRNA levels of expression. Lack of SST did not up-regulate normal CST expression in brain nor did it induce its expression in the periphery. SST-like immunoreactivity, however, was induced in the proximal midgut in SSTKO animals, suggesting intestinal expression of a novel SST-like gene.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Endocrine Society
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Somatostatina
dc.subject
Ratón Knockout
dc.subject.classification
Neurociencias
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Brain somatostatin receptors are up-regulated in somatostatin-deficient mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-07-16T14:13:06Z
dc.journal.volume
16
dc.journal.number
8
dc.journal.pagination
1951-1963
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Baltimore
dc.description.fil
Fil: Ramírez, José L.. McGill University; Canadá
dc.description.fil
Fil: Mouchantaf, Rania. McGill University; Canadá
dc.description.fil
Fil: Kumar, Ujendra. McGill University; Canadá
dc.description.fil
Fil: Otero Corchon, Veronica. Oregon Health and Science University; Estados Unidos
dc.description.fil
Fil: Rubinstein, Marcelo. Oregon Health and Science University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.description.fil
Fil: Low, Malcolm J.. Oregon Health and Science University; Estados Unidos
dc.description.fil
Fil: Patel, Yogesh C.. McGill University; Canadá
dc.journal.title
Molecular Endocrinology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/12145348
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1210/me.2002-0068
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/mend/article/16/8/1951/2741841
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