Artículo
Brain somatostatin receptors are up-regulated in somatostatin-deficient mice
Ramírez, José L.; Mouchantaf, Rania; Kumar, Ujendra; Otero Corchon, Veronica; Rubinstein, Marcelo
; Low, Malcolm J.; Patel, Yogesh C.
Fecha de publicación:
08/2002
Editorial:
Endocrine Society
Revista:
Molecular Endocrinology
ISSN:
0888-8809
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The peptide somatostatin (SST) is widely synthesized in the brain and periphery and acts through a family of five receptors (SSTR1-5) to exert numerous effects. A gene product related to SST, cortistatin (CST), also interacts with SSTR1-5. Here we have investigated the regulation of SSTR1-5 and of CST in SST knockout (SSTKO) mice. The five SSTRs were quantitated individually by subtype-selective binding analysis, by immunocytochemistry, and by mRNA measurement and showed, in the brain of SSTKO mice, up-regulation of subtypes 1, 2, 4, and 5, and down-regulation of SSTR3. Peripheral tissues displayed both subtype- and tissue-specific changes in SSTR1-5 mRNA levels of expression. Lack of SST did not up-regulate normal CST expression in brain nor did it induce its expression in the periphery. SST-like immunoreactivity, however, was induced in the proximal midgut in SSTKO animals, suggesting intestinal expression of a novel SST-like gene.
Palabras clave:
Somatostatina
,
Ratón Knockout
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Articulos(INGEBI)
Articulos de INST.DE INVEST.EN ING.GENETICA Y BIOL.MOLECULAR "DR. HECTOR N TORRES"
Articulos de INST.DE INVEST.EN ING.GENETICA Y BIOL.MOLECULAR "DR. HECTOR N TORRES"
Citación
Ramírez, José L.; Mouchantaf, Rania; Kumar, Ujendra; Otero Corchon, Veronica; Rubinstein, Marcelo; et al.; Brain somatostatin receptors are up-regulated in somatostatin-deficient mice; Endocrine Society; Molecular Endocrinology; 16; 8; 8-2002; 1951-1963
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