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dc.contributor.author
Arias, Hugo Rubén  
dc.contributor.author
Blanton, Michael P.  
dc.date.available
2019-07-01T21:10:07Z  
dc.date.issued
2002-04  
dc.identifier.citation
Arias, Hugo Rubén; Blanton, Michael P.; Molecular and Physicochemical Aspects of Local Anesthetics Acting on Nicotinic Acetylcholine Receptor-containing Membranes; Bentham Science Publishers; Mini-reviews In Medicinal Chemistry; 2; 4; 4-2002; 385-410  
dc.identifier.issn
1389-5575  
dc.identifier.uri
http://hdl.handle.net/11336/78991  
dc.description.abstract
Local anesthetics inhibit the ion channel activity of nicotinic acetylcholine receptors in a noncompetitive fashion. This inhibitory action is ascribed to two possible inhibitory mechanisms: an open-channel-blocking mechanism and/or an allosteric process where the drug binds either to the closed channel or to other nonluminal sites, respectively.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Bentham Science Publishers  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Local Anesthesics  
dc.subject
Nicotinic Acetylcholine Receptors  
dc.subject
Mechanism of Inhibition  
dc.subject
Achrs Memrane  
dc.subject
Open-Channel-Blocking Mechanism  
dc.subject.classification
Farmacología y Farmacia  
dc.subject.classification
Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Molecular and Physicochemical Aspects of Local Anesthetics Acting on Nicotinic Acetylcholine Receptor-containing Membranes  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-06-12T14:21:55Z  
dc.journal.volume
2  
dc.journal.number
4  
dc.journal.pagination
385-410  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Oak Park  
dc.description.fil
Fil: Arias, Hugo Rubén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Texas Tech University Health Sciences Center; Estados Unidos  
dc.description.fil
Fil: Blanton, Michael P.. Texas Tech University Health Sciences Center; Estados Unidos  
dc.journal.title
Mini-reviews In Medicinal Chemistry  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/81400/article/molecular-and-physicochemical-aspects-local-anesthetics-acting-nicotinic-acetylcholine  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2174/1389557023406025  

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