Molecular and Physicochemical Aspects of Local Anesthetics Acting on Nicotinic Acetylcholine Receptor-containing Membranes

Arias, Hugo Rubén; Blanton, Michael P.

doi:10.2174/1389557023406025

Artículo

Molecular and Physicochemical Aspects of Local Anesthetics Acting on Nicotinic Acetylcholine Receptor-containing Membranes

Arias, Hugo Rubén Icon

; Blanton, Michael P.

Fecha de publicación: 04/2002

Editorial: Bentham Science Publishers

Revista: Mini-reviews In Medicinal Chemistry

ISSN: 1389-5575

Idioma: Inglés

Tipo de recurso: Artículo publicado

Clasificación temática:

Farmacología y Farmacia

Resumen

Local anesthetics inhibit the ion channel activity of nicotinic acetylcholine receptors in a noncompetitive fashion. This inhibitory action is ascribed to two possible inhibitory mechanisms: an open-channel-blocking mechanism and/or an allosteric process where the drug binds either to the closed channel or to other nonluminal sites, respectively.

Palabras clave: Local Anesthesics , Nicotinic Acetylcholine Receptors , Mechanism of Inhibition , Achrs Memrane , Open-Channel-Blocking Mechanism

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/78991

URL: http://www.eurekaselect.com/81400/article/molecular-and-physicochemical-aspects-

DOI: http://dx.doi.org/10.2174/1389557023406025

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Articulos(INMABB)
Articulos de INST.DE MATEMATICA BAHIA BLANCA (I)

Citación

Arias, Hugo Rubén; Blanton, Michael P.; Molecular and Physicochemical Aspects of Local Anesthetics Acting on Nicotinic Acetylcholine Receptor-containing Membranes; Bentham Science Publishers; Mini-reviews In Medicinal Chemistry; 2; 4; 4-2002; 385-410

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