Mostrar el registro sencillo del ítem

dc.contributor.author
Albrecht, Martín
dc.contributor.author
Frungieri, Monica Beatriz
dc.contributor.author
Kunz, L.
dc.contributor.author
Rämsch, R.
dc.contributor.author
Meineke, V.
dc.contributor.author
Köhn, F.M.
dc.contributor.author
Mayerhofer, Artur
dc.date.available
2019-06-24T14:41:37Z
dc.date.issued
2005-12
dc.identifier.citation
Albrecht, Martín; Frungieri, Monica Beatriz; Kunz, L.; Rämsch, R.; Meineke, V.; et al.; Divergent effects of the major mast cell products histamine, tryptase and TNF-alpha on human fibroblast behaviour; Birkhauser Verlag Ag; Cellular and Molecular Life Sciences; 62; 23; 12-2005; 2867-2876
dc.identifier.issn
1420-682X
dc.identifier.uri
http://hdl.handle.net/11336/78703
dc.description.abstract
Fibroblast proliferation is a key process in tissue remodeling and mast cells (MCs) are thought to play a crucial role. Having established that the three major MC products, tryptase, histamine and TNF-alpha (TNF) are normally present in human skin MCs, which are in close proximity to dermal fibroblasts, we studied their individual effects on cell cycle-controlled human dermal fibroblasts (HFFF2). These cells express receptors (H1, PAR2, TNFR1/2) for the major MC mediators, but only tryptase or a PAR2 agonist peptide stimulated proliferation and gene expression. TNF was antimitotic, and histamine, while elevating intracellular Ca2+ levels at high concentrations, did not affect proliferation. We conclude that MC products but also composition and numbers of respective receptors on fibroblasts are crucially responsible for fibroproliferative events. © Birkhäuser Verlag, 2005.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Birkhauser Verlag Ag
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Calcium
dc.subject
Histamine
dc.subject
Mast Cell
dc.subject
Proliferation
dc.subject
Tissue Remodeling
dc.subject
Tnf-Alpha
dc.subject
Tryptase
dc.subject.classification
Inmunología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Divergent effects of the major mast cell products histamine, tryptase and TNF-alpha on human fibroblast behaviour
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-05-14T15:51:14Z
dc.journal.volume
62
dc.journal.number
23
dc.journal.pagination
2867-2876
dc.journal.pais
Suiza
dc.journal.ciudad
Basilea
dc.description.fil
Fil: Albrecht, Martín. Ludwig Maximilians Universitat; Alemania
dc.description.fil
Fil: Frungieri, Monica Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Ludwig Maximilians Universitat; Alemania
dc.description.fil
Fil: Kunz, L.. Ludwig Maximilians Universitat; Alemania
dc.description.fil
Fil: Rämsch, R.. Ludwig Maximilians Universitat; Alemania
dc.description.fil
Fil: Meineke, V.. Sanitätsakademie der Bundeswehr; Alemania
dc.description.fil
Fil: Köhn, F.M.. Technical University; Alemania
dc.description.fil
Fil: Mayerhofer, Artur. Ludwig Maximilians Universitat; Alemania
dc.journal.title
Cellular and Molecular Life Sciences
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s00018-005-5289-7
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1007/s00018-005-5289-7


Archivos asociados

Documento no disponible

Comunidades y colecciones

  • Articulos(IBYME) [1164]
    Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)

Mostrar el registro sencillo del ítem