Artículo
Divergent effects of the major mast cell products histamine, tryptase and TNF-alpha on human fibroblast behaviour
Albrecht, Martín; Frungieri, Monica Beatriz
; Kunz, L.; Rämsch, R.; Meineke, V.; Köhn, F.M.; Mayerhofer, Artur
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Fecha de publicación:
12/2005
Editorial:
Birkhauser Verlag Ag
Revista:
Cellular and Molecular Life Sciences
ISSN:
1420-682X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Fibroblast proliferation is a key process in tissue remodeling and mast cells (MCs) are thought to play a crucial role. Having established that the three major MC products, tryptase, histamine and TNF-alpha (TNF) are normally present in human skin MCs, which are in close proximity to dermal fibroblasts, we studied their individual effects on cell cycle-controlled human dermal fibroblasts (HFFF2). These cells express receptors (H1, PAR2, TNFR1/2) for the major MC mediators, but only tryptase or a PAR2 agonist peptide stimulated proliferation and gene expression. TNF was antimitotic, and histamine, while elevating intracellular Ca2+ levels at high concentrations, did not affect proliferation. We conclude that MC products but also composition and numbers of respective receptors on fibroblasts are crucially responsible for fibroproliferative events. © Birkhäuser Verlag, 2005.
Palabras clave:
Calcium
,
Histamine
,
Mast Cell
,
Proliferation
,
Tissue Remodeling
,
Tnf-Alpha
,
Tryptase
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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Albrecht, Martín; Frungieri, Monica Beatriz; Kunz, L.; Rämsch, R.; Meineke, V.; et al.; Divergent effects of the major mast cell products histamine, tryptase and TNF-alpha on human fibroblast behaviour; Birkhauser Verlag Ag; Cellular and Molecular Life Sciences; 62; 23; 12-2005; 2867-2876
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