Artículo
Lyophilized Rhodotorula yeast as all-in-one redox biocatalyst: Access to enantiopure building blocks by simple chemoenzymatic one-pot procedures
Aguirre Pranzoni, Celeste Beatriz
; Bisogno, Fabricio Román
; Orden, Alejandro Agustin
; Kurina Sanz, Marcela Beatriz
Fecha de publicación:
04/2015
Editorial:
Elsevier Science
Revista:
Journal Of Molecular Catalysis B-enzymatic
ISSN:
1381-1177
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Rhodotorula sp. LSL, isolated from a local landfarming was able to catalyze the reduction of prochiral arylketones into sec-alcohols with excellent Prelog stereoselectivity (ee > 99%). The use of resting and lyophilized cells was optimized accessing to an easy-to-use whole cell biocatalyst that efficiently works even under non-sterile conditions, without the addition of external cofactors and using plain water as solvent. The catalyst resistance in alkaline media enabled (chemo)enzymatic one-pot procedures at high pH values. So a simple and efficient methodology was applied to prepare alternatively enantiopure β-halohydrins, terminal diols and epoxides from aromatic α-haloketones.
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Articulos(INFIQC)
Articulos de INST.DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Articulos de INST.DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Articulos(INTEQUI)
Articulos de INST. DE INVEST. EN TECNOLOGIA QUIMICA
Articulos de INST. DE INVEST. EN TECNOLOGIA QUIMICA
Citación
Aguirre Pranzoni, Celeste Beatriz; Bisogno, Fabricio Román; Orden, Alejandro Agustin; Kurina Sanz, Marcela Beatriz; Lyophilized Rhodotorula yeast as all-in-one redox biocatalyst: Access to enantiopure building blocks by simple chemoenzymatic one-pot procedures; Elsevier Science; Journal Of Molecular Catalysis B-enzymatic; 114; 4-2015; 19-24
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