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dc.contributor.author
Haro Durand, Luis Alberto
dc.contributor.author
Vargas, Gabriela Elizabet
dc.contributor.author
Romero, Nélida M.
dc.contributor.author
Vera Mesones, Rosa
dc.contributor.author
Porto Lopez, Jose Manuel
dc.contributor.author
Boccaccini, Aldo R.
dc.contributor.author
Zago, María Paola
dc.contributor.author
Baldi, Alberto
dc.contributor.author
Gorustovich, Alejandro
dc.date.available
2016-08-29T17:25:35Z
dc.date.issued
2015-01
dc.identifier.citation
Haro Durand, Luis Alberto; Vargas, Gabriela Elizabet; Romero, Nélida M.; Vera Mesones, Rosa; Porto Lopez, Jose Manuel; et al.; Angiogenic effects of ionic dissolution products released from a boron-doped 45S5 bioactive glass; Royal Society Of Chemistry; Journal Of Materials Chemistry; 3; 6; 1-2015; 1142-1148
dc.identifier.issn
0959-9428
dc.identifier.uri
http://hdl.handle.net/11336/7333
dc.description.abstract
In regenerative medicine of vascularized tissues, there is a great interest in the use of biomaterials that are able to stimulate angiogenesis, a process necessary for rapid revascularization to allow the transport and exchange of oxygen, nutrients, growth factors and cells that take part in tissue repair and/or regeneration. An increasing number of publications have shown that bioactive glasses stimulate angiogenesis. Because it has been established that boron (B) may play a role in angiogenesis, the aim of this study was to assess the in vivo angiogenic effects of the ionic dissolution products that from a bioactive glass (BG) in the 45S5 system doped with 2 wt% B2O3 (45S5.2B). The pro-angiogenic capacity of 45S5.2B BG was assessed on the vasculature of the embryonic quail chorioallantoic membrane (CAM). Ionic dissolution products from 45S5.2B BG increased angiogenesis. This is quantitatively evidenced by the greater expression of integrin avb3 and higher vascular density in the embryonic quail CAM. The response observed at 2 and 5 days post-treatment was equivalent to that achieved by applying 10 mg mL1 of basic fibroblast growth factor. These results show that the ionic dissolution products released from the bioactive glass 45S5.2B stimulate angiogenesis in vivo. The effects observed are attributed to the presence the ionic dissolution products, which contained 160 10 mM borate.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Royal Society Of Chemistry
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Angiogenesis
dc.subject
Boron
dc.subject
Bioactive Glass
dc.subject.classification
Biomateriales
dc.subject.classification
Biotecnología de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Angiogenic effects of ionic dissolution products released from a boron-doped 45S5 bioactive glass
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-08-04T18:18:26Z
dc.journal.volume
3
dc.journal.number
6
dc.journal.pagination
1142-1148
dc.journal.pais
Reino Unido
dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Haro Durand, Luis Alberto. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Tecnologías y Ciencias de la Ingenieria "Hilario Fernandez Long". Grupo Vinculado al Intecin - Grupo Interdisciplinario en Materiales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil
Fil: Vargas, Gabriela Elizabet. Universidad Nacional de Salta. Facultad de Cs.naturales. Escuela de Biologia; Argentina
dc.description.fil
Fil: Romero, Nélida M.. Universidad Nacional de Salta. Facultad de Cs.naturales. Escuela de Biologia; Argentina
dc.description.fil
Fil: Vera Mesones, Rosa. Universidad Nacional de Salta. Facultad de Cs.naturales. Escuela de Biologia. Catedra de Biologia de Desarrollo; Argentina
dc.description.fil
Fil: Porto Lopez, Jose Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación en Ciencia y Tecnología de Materiales (i); Argentina
dc.description.fil
Fil: Boccaccini, Aldo R.. Universitat Erlangen-Nuremberg; Alemania
dc.description.fil
Fil: Zago, María Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; Argentina
dc.description.fil
Fil: Baldi, Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil
Fil: Gorustovich, Alejandro. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Tecnologías y Ciencias de la Ingenieria "Hilario Fernandez Long". Grupo Vinculado al Intecin - Grupo Interdisciplinario en Materiales; Argentina
dc.journal.title
Journal Of Materials Chemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2014/TB/C4TB01840K#!divAbstract
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1039/C4TB01840K


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