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Artículo

Angiogenic effects of ionic dissolution products released from a boron-doped 45S5 bioactive glass

Haro Durand, Luis AlbertoIcon ; Vargas, Gabriela ElizabetIcon ; Romero, Nélida M.; Vera Mesones, Rosa; Porto Lopez, Jose ManuelIcon ; Boccaccini, Aldo R.; Zago, María PaolaIcon ; Baldi, AlbertoIcon ; Gorustovich, Alejandro
Fecha de publicación: 01/2015
Editorial: Royal Society Of Chemistry
Revista: Journal Of Materials Chemistry
ISSN: 0959-9428
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Biomateriales

Resumen

In regenerative medicine of vascularized tissues, there is a great interest in the use of biomaterials that are able to stimulate angiogenesis, a process necessary for rapid revascularization to allow the transport and exchange of oxygen, nutrients, growth factors and cells that take part in tissue repair and/or regeneration. An increasing number of publications have shown that bioactive glasses stimulate angiogenesis. Because it has been established that boron (B) may play a role in angiogenesis, the aim of this study was to assess the in vivo angiogenic effects of the ionic dissolution products that from a bioactive glass (BG) in the 45S5 system doped with 2 wt% B2O3 (45S5.2B). The pro-angiogenic capacity of 45S5.2B BG was assessed on the vasculature of the embryonic quail chorioallantoic membrane (CAM). Ionic dissolution products from 45S5.2B BG increased angiogenesis. This is quantitatively evidenced by the greater expression of integrin avb3 and higher vascular density in the embryonic quail CAM. The response observed at 2 and 5 days post-treatment was equivalent to that achieved by applying 10 mg mL1 of basic fibroblast growth factor. These results show that the ionic dissolution products released from the bioactive glass 45S5.2B stimulate angiogenesis in vivo. The effects observed are attributed to the presence the ionic dissolution products, which contained 160 10 mM borate.
Palabras clave: Angiogenesis , Boron , Bioactive Glass
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/7333
URL: http://pubs.rsc.org/en/Content/ArticleLanding/2014/TB/C4TB01840K#!divAbstract
DOI: http://dx.doi.org/10.1039/C4TB01840K
Colecciones
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos(CCT - SALTA-JUJUY)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - SALTA-JUJUY
Articulos(IPE)
Articulos de INST.DE PATOLOGIA EXPERIMENTAL
Citación
Haro Durand, Luis Alberto; Vargas, Gabriela Elizabet; Romero, Nélida M.; Vera Mesones, Rosa; Porto Lopez, Jose Manuel; et al.; Angiogenic effects of ionic dissolution products released from a boron-doped 45S5 bioactive glass; Royal Society Of Chemistry; Journal Of Materials Chemistry; 3; 6; 1-2015; 1142-1148
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