Artículo
An efficient biotransformation of dialkyl esters of 2-oxoglutaric acid by Rhodotorula minuta whole cells
Fecha de publicación:
07/2008
Editorial:
Taylor & Francis Ltd
Revista:
Biocatalysis and Biotransformation
ISSN:
1024-2422
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Whole cells of the yeast Rhodotorula minuta were used in the biotransformation of dialkyl esters of 2-oxoglutaric acid. Almost 100% of conversion with 97-98% of enantiomeric excess of the (S) form of 2-hydroxydiesters was obtained through an enantioselective reduction of dimethyl and diethyl 2-oxoglutarate. When longer alkoxy chain 2-oxoglutarates were used as substrates, the corresponding 4-hydroxybutyric esters were obtained, suggesting a combination process including hydrolysis, decarboxylation and reduction. The cells showed a remarkable high productivity: high conversion and enantiomeric excess were obtained at 2 g wet weight mmol-1 substrate.
Palabras clave:
Biotransformation
,
Dialkyl 2-Oxoglutaric Acid Esters
,
Rhodotorula Minuta
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Articulos(UMYMFOR)
Articulos de UNID.MICROANAL.Y MET.FISICOS EN QUIM.ORG.(I)
Articulos de UNID.MICROANAL.Y MET.FISICOS EN QUIM.ORG.(I)
Citación
Rustoy, Eduardo Miguel; Cerrutti, Patricia; Galvagno, Miguel Angel; Baldessari, Alicia; An efficient biotransformation of dialkyl esters of 2-oxoglutaric acid by Rhodotorula minuta whole cells; Taylor & Francis Ltd; Biocatalysis and Biotransformation; 26; 3; 7-2008; 204-209
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