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dc.contributor.author
Moreno Torrejon, Laura  
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Lopez Urbina, L.  
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Farias, Cristina Elena  
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Domingue, G.  
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Donadeu, M.  
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Dungu, B.  
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García, H. H.  
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Gomez Puerta, L. A.  
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Lanusse, Carlos Edmundo  
dc.contributor.author
González, A. E.  
dc.date.available
2019-02-06T23:07:24Z  
dc.date.issued
2012-10  
dc.identifier.citation
Moreno Torrejon, Laura; Lopez Urbina, L.; Farias, Cristina Elena; Domingue, G.; Donadeu, M.; et al.; A high oxfendazole dose to control porcine cysticercosis: Pharmacokinetics and tissue residue profiles; Pergamon-Elsevier Science Ltd; Food And Chemical Toxicology; 50; 10; 10-2012; 3819-3825  
dc.identifier.issn
0278-6915  
dc.identifier.uri
http://hdl.handle.net/11336/69618  
dc.description.abstract
Oxfendazole (OFZ) is efficacious for porcine cysticercosis at 30mg/kg. OFZ is not registered to be used at this dose. The assessment of the OFZ and metabolites [(fenbendazole sulphone (FBZSO2), fenbendazole (FBZ)] plasma pharmacokinetic and tissue residue profiles after its oral administration to pigs and the withdrawal period for human consumption were reported. Forty-eight pigs allocated into two groups received OFZ (30mg/kg) orally as a commercial (CF) or as experimental formulation (SMF). Samples (blood, muscle, liver, kidney and fat) were collected over 30days post-treatment and analyzed by HPLC. OFZ was the main compound recovered in plasma, followed by FBZSO2 and low FBZ concentrations. OFZ AUC0-LOQ (209.9±33.9μg·h/ml) and Cmax (5.40±0.65μg/ml) parameters for the CF tended to be higher than those for the SMF (AUC0-LOQ: 159.4±18.3μgh/ml, Cmax: 3.80±0.35μg/ml). The highest total residue (OFZ+FBZSO2+FBZ) concentrations were quantified in liver, followed by kidney, muscle and fat tissue. FBZSO2 residue levels were the highest found in muscle (0.68±0.39μg/g) and fat (0.69±0.39μg/g). In liver and kidney the highest residues corresponded to FBZ (5.29±4.36μg/g) and OFZ (2.86±0.75μg/g), respectively. A withdrawal time of 17days post-treatment was established before tissues are delivered for human consumption.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Pergamon-Elsevier Science Ltd  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Cysticercosis  
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Oxfendazole  
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Pharmacokinetics  
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Tissue Residues  
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Withdrawal Time  
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Alimentos y Bebidas  
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Otras Ingenierías y Tecnologías  
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INGENIERÍAS Y TECNOLOGÍAS  
dc.title
A high oxfendazole dose to control porcine cysticercosis: Pharmacokinetics and tissue residue profiles  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-01-23T18:53:51Z  
dc.journal.volume
50  
dc.journal.number
10  
dc.journal.pagination
3819-3825  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Moreno Torrejon, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina  
dc.description.fil
Fil: Lopez Urbina, L.. Universidad Nacional Mayor de San Marcos; Perú  
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Fil: Farias, Cristina Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina  
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Fil: Domingue, G.. Express Microbiology Ltd.; Reino Unido  
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Fil: Donadeu, M.. Global Alliance for Livestock Veterinary Medicines; Reino Unido  
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Fil: Dungu, B.. Global Alliance for Livestock Veterinary Medicines; Reino Unido  
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Fil: García, H. H.. Universidad Peruana Cayetano Heredia; Perú. Instituto Nacional de Ciencias Neurológicas; Perú. Cysticercosis Working Group; Perú  
dc.description.fil
Fil: Gomez Puerta, L. A.. Universidad Nacional Mayor de San Marcos; Perú. Cysticercosis Working Group; Perú  
dc.description.fil
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina  
dc.description.fil
Fil: González, A. E.. Universidad Nacional Mayor de San Marcos; Perú. Cysticercosis Working Group; Perú  
dc.journal.title
Food And Chemical Toxicology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.fct.2012.07.023  
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info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0278691512005017