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dc.contributor.author
Moreno Torrejon, Laura
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Lopez Urbina, L.
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Farias, Cristina Elena
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Domingue, G.
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Donadeu, M.
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Dungu, B.
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García, H. H.
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Gomez Puerta, L. A.
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Lanusse, Carlos Edmundo
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González, A. E.
dc.date.available
2019-02-06T23:07:24Z
dc.date.issued
2012-10
dc.identifier.citation
Moreno Torrejon, Laura; Lopez Urbina, L.; Farias, Cristina Elena; Domingue, G.; Donadeu, M.; et al.; A high oxfendazole dose to control porcine cysticercosis: Pharmacokinetics and tissue residue profiles; Pergamon-Elsevier Science Ltd; Food And Chemical Toxicology; 50; 10; 10-2012; 3819-3825
dc.identifier.issn
0278-6915
dc.identifier.uri
http://hdl.handle.net/11336/69618
dc.description.abstract
Oxfendazole (OFZ) is efficacious for porcine cysticercosis at 30mg/kg. OFZ is not registered to be used at this dose. The assessment of the OFZ and metabolites [(fenbendazole sulphone (FBZSO2), fenbendazole (FBZ)] plasma pharmacokinetic and tissue residue profiles after its oral administration to pigs and the withdrawal period for human consumption were reported. Forty-eight pigs allocated into two groups received OFZ (30mg/kg) orally as a commercial (CF) or as experimental formulation (SMF). Samples (blood, muscle, liver, kidney and fat) were collected over 30days post-treatment and analyzed by HPLC. OFZ was the main compound recovered in plasma, followed by FBZSO2 and low FBZ concentrations. OFZ AUC0-LOQ (209.9±33.9μg·h/ml) and Cmax (5.40±0.65μg/ml) parameters for the CF tended to be higher than those for the SMF (AUC0-LOQ: 159.4±18.3μgh/ml, Cmax: 3.80±0.35μg/ml). The highest total residue (OFZ+FBZSO2+FBZ) concentrations were quantified in liver, followed by kidney, muscle and fat tissue. FBZSO2 residue levels were the highest found in muscle (0.68±0.39μg/g) and fat (0.69±0.39μg/g). In liver and kidney the highest residues corresponded to FBZ (5.29±4.36μg/g) and OFZ (2.86±0.75μg/g), respectively. A withdrawal time of 17days post-treatment was established before tissues are delivered for human consumption.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Cysticercosis
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Oxfendazole
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Pharmacokinetics
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Tissue Residues
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Withdrawal Time
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Alimentos y Bebidas
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Otras Ingenierías y Tecnologías
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
A high oxfendazole dose to control porcine cysticercosis: Pharmacokinetics and tissue residue profiles
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-01-23T18:53:51Z
dc.journal.volume
50
dc.journal.number
10
dc.journal.pagination
3819-3825
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Moreno Torrejon, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
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Fil: Lopez Urbina, L.. Universidad Nacional Mayor de San Marcos; Perú
dc.description.fil
Fil: Farias, Cristina Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
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Fil: Domingue, G.. Express Microbiology Ltd.; Reino Unido
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Fil: Donadeu, M.. Global Alliance for Livestock Veterinary Medicines; Reino Unido
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Fil: Dungu, B.. Global Alliance for Livestock Veterinary Medicines; Reino Unido
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Fil: García, H. H.. Universidad Peruana Cayetano Heredia; Perú. Instituto Nacional de Ciencias Neurológicas; Perú. Cysticercosis Working Group; Perú
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Fil: Gomez Puerta, L. A.. Universidad Nacional Mayor de San Marcos; Perú. Cysticercosis Working Group; Perú
dc.description.fil
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
dc.description.fil
Fil: González, A. E.. Universidad Nacional Mayor de San Marcos; Perú. Cysticercosis Working Group; Perú
dc.journal.title
Food And Chemical Toxicology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.fct.2012.07.023
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0278691512005017
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