Artículo
A high oxfendazole dose to control porcine cysticercosis: Pharmacokinetics and tissue residue profiles
Moreno Torrejon, Laura
; Lopez Urbina, L.; Farias, Cristina Elena
; Domingue, G.; Donadeu, M.; Dungu, B.; García, H. H.; Gomez Puerta, L. A.; Lanusse, Carlos Edmundo
; González, A. E.
Fecha de publicación:
10/2012
Editorial:
Pergamon-Elsevier Science Ltd
Revista:
Food And Chemical Toxicology
ISSN:
0278-6915
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Oxfendazole (OFZ) is efficacious for porcine cysticercosis at 30mg/kg. OFZ is not registered to be used at this dose. The assessment of the OFZ and metabolites [(fenbendazole sulphone (FBZSO2), fenbendazole (FBZ)] plasma pharmacokinetic and tissue residue profiles after its oral administration to pigs and the withdrawal period for human consumption were reported. Forty-eight pigs allocated into two groups received OFZ (30mg/kg) orally as a commercial (CF) or as experimental formulation (SMF). Samples (blood, muscle, liver, kidney and fat) were collected over 30days post-treatment and analyzed by HPLC. OFZ was the main compound recovered in plasma, followed by FBZSO2 and low FBZ concentrations. OFZ AUC0-LOQ (209.9±33.9μg·h/ml) and Cmax (5.40±0.65μg/ml) parameters for the CF tended to be higher than those for the SMF (AUC0-LOQ: 159.4±18.3μgh/ml, Cmax: 3.80±0.35μg/ml). The highest total residue (OFZ+FBZSO2+FBZ) concentrations were quantified in liver, followed by kidney, muscle and fat tissue. FBZSO2 residue levels were the highest found in muscle (0.68±0.39μg/g) and fat (0.69±0.39μg/g). In liver and kidney the highest residues corresponded to FBZ (5.29±4.36μg/g) and OFZ (2.86±0.75μg/g), respectively. A withdrawal time of 17days post-treatment was established before tissues are delivered for human consumption.
Palabras clave:
Cysticercosis
,
Oxfendazole
,
Pharmacokinetics
,
Tissue Residues
,
Withdrawal Time
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CIVETAN)
Articulos de CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Articulos de CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Citación
Moreno Torrejon, Laura; Lopez Urbina, L.; Farias, Cristina Elena; Domingue, G.; Donadeu, M.; et al.; A high oxfendazole dose to control porcine cysticercosis: Pharmacokinetics and tissue residue profiles; Pergamon-Elsevier Science Ltd; Food And Chemical Toxicology; 50; 10; 10-2012; 3819-3825
Compartir
Altmétricas