Artículo

Antiproliferative activity of synthetic naphthoquinones related to lapachol. First synthesis of 5-hydroxylapachol

Bonifazi, Evelyn LuciaIcon ; Ríos Luci, Carla; Leon, Leticia G.; Burton, GerardoIcon ; Padron, Jose; Misico, Rosana IsabelIcon
Fecha de publicación: 04/2010
Editorial: Pergamon-Elsevier Science Ltd
Revista: Bioorganic & Medicinal Chemistry
ISSN: 0968-0896
Idioma: Inglés
Tipo de recurso: Artículo publicado

Resumen

A series of 5-hydroxy-1,4-naphthoquinones analogues was synthesized from juglone (6) and their antiproliferative activity against a representative panel of six human solid tumor cell lines has been investigated. The 2,5-dihydroxy-3-(3-methylbut-2-enyl)naphthalene-1,4-dione (4) and 2,3-dihydro-5-hydroxy-2-(prop-1-en-2-yl)naphtho[2,3-b]furan-4,9-dione (27) were the most potent antiproliferative agents with GI50 values of 0.42-8.1 and 0.80-2.2 μM, respectively. The results provide insight into the correlation between some structural properties of 5-hydroxynaphthoquinones and their antiproliferative activity.

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http://www.sciencedirect.com/science/article/pii/S0968089610001537
https://doi.org/10.1016/j.bmc.2010.02.032
info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Citación: Bonifazi, Evelyn Lucia; Ríos Luci, Carla; Leon, Leticia G.; Burton, Gerardo; Padron, Jose; et al.; Antiproliferative activity of synthetic naphthoquinones related to lapachol. First synthesis of 5-hydroxylapachol; Pergamon-Elsevier Science Ltd; Bioorganic & Medicinal Chemistry; 18; 7; 4-2010; 2621-2630
URI: http://hdl.handle.net/11336/69496
 

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