Synthesis of aromatic stigmastanes: Application to the synthesis of aromatic analogs of brassinosteroids

In this paper, we report the first synthesis of aromatic analogs of brassinosteroids. In order to accomplish this task, we explored two different synthetic approaches, which involved demethylation of the C-19 of stigmasterol to yield A-ring aromatic 3-hydroxystigmastanes. One of the new aromatic analogs showed a reduced but significant bioactivity when compared to the natural hormones.

Palabras clave: A-Ring , Aromatic Stigmastanes , Bioactivity , Brassinosteroids

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/69385

DOI: https://doi.org/10.1016/j.tet.2012.03.082

URL: https://www.sciencedirect.com/science/article/pii/S0040402012004231

Colecciones

Articulos(UMYMFOR)
Articulos de UNID.MICROANAL.Y MET.FISICOS EN QUIM.ORG.(I)

Citación

Acebedo, Sofía Lorena; Alonso, Fernando; Ramirez, Javier Alberto; Galagovsky, Lydia Raquel; Synthesis of aromatic stigmastanes: Application to the synthesis of aromatic analogs of brassinosteroids; Pergamon-Elsevier Science Ltd; Tetrahedron; 68; 19; 5-2012; 3685-3691

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