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dc.contributor.author Inbar, Ehud
dc.contributor.author Canepa, Gaspar Exequiel
dc.contributor.author Carrillo, Carolina
dc.contributor.author Glaser, Fabian
dc.contributor.author Grotemeyer, Marianne Suter
dc.contributor.author Rentsch, Doris
dc.contributor.author Zilberstein, Dan
dc.contributor.author Pereira, Claudio Alejandro
dc.date.available 2019-01-30T19:03:59Z
dc.date.issued 2012-01
dc.identifier.citation Inbar, Ehud; Canepa, Gaspar Exequiel; Carrillo, Carolina; Glaser, Fabian; Grotemeyer, Marianne Suter; et al.; Lysine transporters in human trypanosomatid pathogens; Springer Wien; Amino Acids; 42; 1; 1-2012; 347-360
dc.identifier.issn 0939-4451
dc.identifier.uri http://hdl.handle.net/11336/69048
dc.description.abstract In previous studies we characterized arginine transporter genes from Trypanosoma cruzi and Leishmania donovani, the etiological agents of chagas disease and kala azar, respectively, both fatal diseases in humans. Unlike arginine transporters in higher eukaryotes that transport also lysine, these parasite transporters translocate only arginine. This phenomenon prompted us to identify and characterize parasite lysine transporters. Here we demonstrate that LdAAP7 and TcAAP7 encode lysine-specific permeases in L. donovani and T. cruzi, respectively. These two lysine permeases are both members of the large amino acid/auxin permease family and share certain biochemical properties, such as specificity and Km. However, we evidence that LdAAP7 and TcAAP7 differ in their regulation and localization, such differences are likely a reflection of the dissimilar L. donovani and T. cruzi life cycles. Failed attempts to delete both alleles of LdAAP7 support the premise that this is an essential gene that encodes the only lysine permeases expressed in L. donovani promastigotes and T. cruzi epimastigotes, respectively.
dc.format application/pdf
dc.language.iso eng
dc.publisher Springer Wien
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject AMINO ACID TRANSPORT
dc.subject LEISHMANIA
dc.subject LYSINE TRANSPORT
dc.subject TRYPANOSOMA
dc.subject.classification Otras Ciencias Biológicas
dc.subject.classification Ciencias Biológicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title Lysine transporters in human trypanosomatid pathogens
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2019-01-29T18:07:25Z
dc.identifier.eissn 1438-2199
dc.journal.volume 42
dc.journal.number 1
dc.journal.pagination 347-360
dc.journal.pais Austria
dc.journal.ciudad Viena
dc.description.fil Fil: Inbar, Ehud. Technion - Israel Institute of Technology; Israel
dc.description.fil Fil: Canepa, Gaspar Exequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil Fil: Carrillo, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología "Dr. César Milstein"; Argentina. Fundación Instituto Leloir; Argentina
dc.description.fil Fil: Glaser, Fabian. Technion - Israel Institute of Technology; Israel
dc.description.fil Fil: Grotemeyer, Marianne Suter. University of Bern; Suiza
dc.description.fil Fil: Rentsch, Doris. University of Bern; Suiza
dc.description.fil Fil: Zilberstein, Dan. Technion - Israel Institute of Technology; Israel
dc.description.fil Fil: Pereira, Claudio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.journal.title Amino Acids
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00726-010-0812-z
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00726-010-0812-z
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)