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dc.contributor.author
Inbar, Ehud
dc.contributor.author
Canepa, Gaspar Exequiel
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Carrillo, Carolina
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Glaser, Fabian
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Grotemeyer, Marianne Suter
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Rentsch, Doris
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Zilberstein, Dan
dc.contributor.author
Pereira, Claudio Alejandro
dc.date.available
2019-01-30T19:03:59Z
dc.date.issued
2012-01
dc.identifier.citation
Inbar, Ehud; Canepa, Gaspar Exequiel; Carrillo, Carolina; Glaser, Fabian; Grotemeyer, Marianne Suter; et al.; Lysine transporters in human trypanosomatid pathogens; Springer Wien; Amino Acids; 42; 1; 1-2012; 347-360
dc.identifier.issn
0939-4451
dc.identifier.uri
http://hdl.handle.net/11336/69048
dc.description.abstract
In previous studies we characterized arginine transporter genes from Trypanosoma cruzi and Leishmania donovani, the etiological agents of chagas disease and kala azar, respectively, both fatal diseases in humans. Unlike arginine transporters in higher eukaryotes that transport also lysine, these parasite transporters translocate only arginine. This phenomenon prompted us to identify and characterize parasite lysine transporters. Here we demonstrate that LdAAP7 and TcAAP7 encode lysine-specific permeases in L. donovani and T. cruzi, respectively. These two lysine permeases are both members of the large amino acid/auxin permease family and share certain biochemical properties, such as specificity and Km. However, we evidence that LdAAP7 and TcAAP7 differ in their regulation and localization, such differences are likely a reflection of the dissimilar L. donovani and T. cruzi life cycles. Failed attempts to delete both alleles of LdAAP7 support the premise that this is an essential gene that encodes the only lysine permeases expressed in L. donovani promastigotes and T. cruzi epimastigotes, respectively.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer Wien
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Amino Acid Transport
dc.subject
Leishmania
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Lysine Transport
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Trypanosoma
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Lysine transporters in human trypanosomatid pathogens
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-01-29T18:07:25Z
dc.identifier.eissn
1438-2199
dc.journal.volume
42
dc.journal.number
1
dc.journal.pagination
347-360
dc.journal.pais
Austria
dc.journal.ciudad
Viena
dc.description.fil
Fil: Inbar, Ehud. Technion - Israel Institute of Technology; Israel
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Fil: Canepa, Gaspar Exequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil
Fil: Carrillo, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología "Dr. César Milstein"; Argentina. Fundación Instituto Leloir; Argentina
dc.description.fil
Fil: Glaser, Fabian. Technion - Israel Institute of Technology; Israel
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Fil: Grotemeyer, Marianne Suter. University of Bern; Suiza
dc.description.fil
Fil: Rentsch, Doris. University of Bern; Suiza
dc.description.fil
Fil: Zilberstein, Dan. Technion - Israel Institute of Technology; Israel
dc.description.fil
Fil: Pereira, Claudio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.journal.title
Amino Acids
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00726-010-0812-z
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00726-010-0812-z


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