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dc.contributor.author
Dasgupta, Indrani
dc.contributor.author
Tanifum, Eric A.
dc.contributor.author
Srivastava, Mayank
dc.contributor.author
Phatak, Sharangdhar S.
dc.contributor.author
Cavasotto, Claudio Norberto
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dc.contributor.author
Analoui, Mostafa
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Annapragada, Ananth
dc.date.available
2019-01-29T21:00:08Z
dc.date.issued
2012-01
dc.identifier.citation
Dasgupta, Indrani; Tanifum, Eric A.; Srivastava, Mayank; Phatak, Sharangdhar S.; Cavasotto, Claudio Norberto; et al.; Non inflammatory boronate based glucose-responsive insulin delivery systems; Public Library of Science; Plos One; 7; 1; 1-2012; 1-11; e29585
dc.identifier.uri
http://hdl.handle.net/11336/68938
dc.description.abstract
Boronic acids, known to bind diols, were screened to identify non-inflammatory cross-linkers for the preparation of glucose sensitive and insulin releasing agglomerates of liposomes (Agglomerated Vesicle Technology-AVT). This was done in order to select a suitable replacement for the previously used cross-linker, ConcanavalinA (ConA), a lectin known to have both toxic and inflammatory effects in vivo. Lead-compounds were selected from screens that involved testing for inflammatory potential, cytotoxicity and glucose-binding. These were then conjugated to insulin-encapsulating nanoparticles and agglomerated via sugar-boronate ester linkages to form AVTs. In vitro, the particles demonstrated triggered release of insulin upon exposure to physiologically relevant concentrations of glucose (10 mmoles/L-40 mmoles/L). The agglomerates were also shown to be responsive to multiple spikes in glucose levels over several hours, releasing insulin at a rate defined by the concentration of the glucose trigger.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library of Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Drug Delivery
dc.subject
Insulin Delivery Systems
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Inflamation
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Boronates
dc.subject.classification
Otras Ciencias Químicas
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Non inflammatory boronate based glucose-responsive insulin delivery systems
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-01-29T18:09:42Z
dc.identifier.eissn
1932-6203
dc.journal.volume
7
dc.journal.number
1
dc.journal.pagination
1-11; e29585
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
San Francisco
dc.description.fil
Fil: Dasgupta, Indrani. University of Texas; Estados Unidos
dc.description.fil
Fil: Tanifum, Eric A.. Baylor College of Medicine; Estados Unidos
dc.description.fil
Fil: Srivastava, Mayank. Baylor College of Medicine; Estados Unidos
dc.description.fil
Fil: Phatak, Sharangdhar S.. University of Texas; Estados Unidos
dc.description.fil
Fil: Cavasotto, Claudio Norberto. University of Texas; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Analoui, Mostafa. Cense Biosciences; Estados Unidos
dc.description.fil
Fil: Annapragada, Ananth. Baylor College of Medicine; Estados Unidos
dc.journal.title
Plos One
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pone.0029585
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029585
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