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Artículo

Non inflammatory boronate based glucose-responsive insulin delivery systems

Dasgupta, Indrani; Tanifum, Eric A.; Srivastava, Mayank; Phatak, Sharangdhar S.; Cavasotto, Claudio NorbertoIcon ; Analoui, Mostafa; Annapragada, Ananth
Fecha de publicación: 01/2012
Editorial: Public Library of Science
Revista: Plos One
e-ISSN: 1932-6203
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
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Resumen

Boronic acids, known to bind diols, were screened to identify non-inflammatory cross-linkers for the preparation of glucose sensitive and insulin releasing agglomerates of liposomes (Agglomerated Vesicle Technology-AVT). This was done in order to select a suitable replacement for the previously used cross-linker, ConcanavalinA (ConA), a lectin known to have both toxic and inflammatory effects in vivo. Lead-compounds were selected from screens that involved testing for inflammatory potential, cytotoxicity and glucose-binding. These were then conjugated to insulin-encapsulating nanoparticles and agglomerated via sugar-boronate ester linkages to form AVTs. In vitro, the particles demonstrated triggered release of insulin upon exposure to physiologically relevant concentrations of glucose (10 mmoles/L-40 mmoles/L). The agglomerates were also shown to be responsive to multiple spikes in glucose levels over several hours, releasing insulin at a rate defined by the concentration of the glucose trigger.
Palabras clave: Drug Delivery , Insulin Delivery Systems , Inflamation , Boronates
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/68938
DOI: http://dx.doi.org/10.1371/journal.pone.0029585
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029585
Colecciones
Articulos(IBIOBA - MPSP)
Articulos de INST. D/INV.EN BIOMED.DE BS AS-CONICET-INST. PARTNER SOCIEDAD MAX PLANCK
Citación
Dasgupta, Indrani; Tanifum, Eric A.; Srivastava, Mayank; Phatak, Sharangdhar S.; Cavasotto, Claudio Norberto; et al.; Non inflammatory boronate based glucose-responsive insulin delivery systems; Public Library of Science; Plos One; 7; 1; 1-2012; 1-11; e29585
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