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dc.contributor.author
Odeon, Maria Mercedes
dc.contributor.author
Salatino, Adrián Emanuel
dc.contributor.author
Rodríguez, Carla Beatriz
dc.contributor.author
Scolari, Mariano José
dc.contributor.author
Acosta, Gabriela Beatriz
dc.date.available
2019-01-08T18:55:06Z
dc.date.issued
2010-07
dc.identifier.citation
Odeon, Maria Mercedes; Salatino, Adrián Emanuel; Rodríguez, Carla Beatriz; Scolari, Mariano José; Acosta, Gabriela Beatriz; The response to postnatal stress: Amino acids transporters and pkc activity; Springer/Plenum Publishers; Neurochemical Research; 35; 7; 7-2010; 967-975
dc.identifier.issn
0364-3190
dc.identifier.uri
http://hdl.handle.net/11336/67668
dc.description.abstract
During postnatal development, the central nervous system (CNS) is highly sensitive to effects of drugs, stressors and environment. In this study, we evaluated the effect of acute cold stress on g-aminobutyric acid (GABA) and L-serine (L-Ser) transporters in vitro, using the uptake of [3H]GABA and [3H]L-Ser by synaptosomes-enriched fractions isolated from rat cerebral cortex during postnatal development. We found that the maximal velocity (Vmax) L-Ser uptake after stress session was increased in almost all ages studied, except at postnatal-days (PD) 5, whereas the values of Km (uptake affinity) decreased in all ages from 5 to 21 PD compared with the control group. The highest values of Vmax and Km were obtained at PD7. At the same time, in GABA uptake, the Km decreased although Vmax increased in all ages considered after cold stress during development. Finally, we investigated the mechanism by which cells regulate the substrate affinity of L-serine and GABA transporters. We demonstrated a significantly increase in PKC activity to PD5 from PD21. Pretreatment with PKC inhibitor: staurosporine (SP) led to a restoration of control uptake in several postnatal-days suggesting a relationship between amino acids uptake and PKC activation. These findings suggest that a single exposure to postnatal cold stress at different periods after birth modifies both GABA and L-Ser transporters and the related increase in PKC activity could be intracellular events that participate in neuronal plasticity by early-life stress, which could be relevant to function of transporters in the adult rat brain.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer/Plenum Publishers
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Acute Cold Stress
dc.subject
Gaba
dc.subject
L-Serina
dc.subject
Pkc
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Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
The response to postnatal stress: Amino acids transporters and pkc activity
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-01-07T13:55:48Z
dc.identifier.eissn
1573-6903
dc.journal.volume
35
dc.journal.number
7
dc.journal.pagination
967-975
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Odeon, Maria Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina
dc.description.fil
Fil: Salatino, Adrián Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina
dc.description.fil
Fil: Rodríguez, Carla Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina
dc.description.fil
Fil: Scolari, Mariano José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina
dc.description.fil
Fil: Acosta, Gabriela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina
dc.journal.title
Neurochemical Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1007/s11064-010-0153-z
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s11064-010-0153-z
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