Artículo

Mechanisms involved in the expansion of Tregs during pregnancy: Role of IL-2/STAT5 signalling

Arruvito, Maria LourdesIcon ; Fainboim, LeonardoIcon
Fecha de publicación: 03/2011
Editorial: Elsevier Ireland
Revista: Journal of Reproductive Immunology
ISSN: 0165-0378
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

Several studies have reported that the fine-tuning of regulatory T cells (Tregs) is required for a successful pregnancy and for the control of autoimmune diseases. Here, we review the mechanisms that control the expansion of Tregs, based on insights obtained from the study of women suffering unsuccessful pregnancies and on recent data from patients with autoimmune diseases or with chronic viral infections such as HCV. In particular, we review the role of endocrine factors and IL-2/STAT5 signalling in the impaired expansion of Tregs.
Palabras clave: Human Reproduction , Il-2 , Regulatory T Cell , Stat-5
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/67626
DOI: https://doi.org/10.1016/j.jri.2010.12.007
URL: https://www.sciencedirect.com/science/article/pii/S0165037811000064
Colecciones
Articulos(INIGEM)
Articulos de INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Citación
Arruvito, Maria Lourdes; Fainboim, Leonardo; Mechanisms involved in the expansion of Tregs during pregnancy: Role of IL-2/STAT5 signalling; Elsevier Ireland; Journal of Reproductive Immunology; 88; 2; 3-2011; 93-98
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