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dc.contributor.author
Araujo, A. S. R.
dc.contributor.author
Seibel, F. E. R.
dc.contributor.author
Fernandes, T.
dc.contributor.author
Llesuy, Susana Francisca
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dc.contributor.author
Kucharski, L.
dc.contributor.author
Belló Klein, A.
dc.date.available
2019-01-04T20:26:34Z
dc.date.issued
2011-07
dc.identifier.citation
Araujo, A. S. R.; Seibel, F. E. R.; Fernandes, T.; Llesuy, Susana Francisca; Kucharski, L.; et al.; Thyroid hormone-induced haemoglobin changes and antioxidant enzymes response in erythrocytes; John Wiley & Sons Ltd; Cell Biochemistry And Function; 29; 5; 7-2011; 408-413
dc.identifier.issn
0263-6484
dc.identifier.uri
http://hdl.handle.net/11336/67465
dc.description.abstract
Thyroid hormones modulate haemoglobin and reactive oxygen species (ROS) production, leading to antioxidant changes. This study evaluated the antioxidant response to ROS in erythrocytes in hypothyroid and hyperthyroid rats. Wistar rats were divided into four groups: control; hyperthyroid (T4-12mgl-1 in drinking water); sham operated (simulation of thyroidectomy); and hypothyroid (thyroidectomized). Four weeks after, blood was collected and haemoglobin and T4 levels, lipid peroxidation (LPO), protein oxidation, superoxide dismutase (SOD), catalase (CAT) , glutathione S-transferase (GST) and glutathione peroxidase (GPx) activities, and total radical antioxidant potential (TRAP) were measured. SOD, CAT and GST immunocontent was evaluated. Haemoglobin levels were increased in hyperthyroid erythrocytes. LPO and carbonyls were augmented (65% and 55%, respectively) in hyperthyroid and reduced (31% and 56%, respectively) in hypothyroid group. SOD and CAT activities have not changed, as well as CAT immunocontent. TRAP was diminished in both hyperthyroid and hypothyroid groups (36% and 37%, respectively). GST activity and immunocontent, as well as GPx activity, were increased in hyper and hypothyroid rats. The data suggest that thyroid hormone changes determine ROS concentration changes and decrease of some antioxidant defences that would lead to a compensatory answer of the GST and GPx enzymes, which could be consider as credible biomarkers.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
John Wiley & Sons Ltd
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Blood-Biomarkers
dc.subject
Gpx
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Gst
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Hyperthyroidism
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Hypothyroidism
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Oxidative Damage
dc.subject.classification
Otras Medicina Básica
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Thyroid hormone-induced haemoglobin changes and antioxidant enzymes response in erythrocytes
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-01-04T16:29:58Z
dc.journal.volume
29
dc.journal.number
5
dc.journal.pagination
408-413
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Araujo, A. S. R.. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil
Fil: Seibel, F. E. R.. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil
Fil: Fernandes, T.. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
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Fil: Kucharski, L.. Universidade Federal do Rio Grande do Sul; Brasil
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Fil: Belló Klein, A.. Universidade Federal do Rio Grande do Sul; Brasil
dc.journal.title
Cell Biochemistry And Function
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/cbf.1765
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/cbf.1765
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