Artículo
Label-free biosensing based on multilayer fluorescent nanocomposites and a cationic polymeric transducer
Fecha de publicación:
03/2011
Editorial:
American Chemical Society
Revista:
ACS Nano
ISSN:
1936-0851
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
This study describes the preparation and characterization of a DNA sensing architecture combining the molecular recognition capabilities of a cationic conjugated polymer transducer with highly fluorescent core-shell nanoparticles (NPs). The very structure of the probe-labeled NPs and the polymer-induced formation of NP aggregates maximize the proximity between the polymer donor and acceptor NPs that is required for optimal resonant energy transfer. Each hybridization event is signaled by a potentially large number of excited reporters following the efficient plasmon-enhanced energy transfer between target-activated polymer transducer and fluorophores located in the self-assembled core-shell aggregates, resulting in direct molecular detection of target nucleic acids at femtomolar concentrations. © 2011 American Chemical Society.
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Articulos(INFIQC)
Articulos de INST.DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Articulos de INST.DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Citación
Brouard, Danny; Viger, Mathieu L.; Bracamonte, Angel Guillermo; Boudreau, Denis; Label-free biosensing based on multilayer fluorescent nanocomposites and a cationic polymeric transducer; American Chemical Society; ACS Nano; 5; 3; 3-2011; 1888-1896
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