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dc.contributor.author
Stachon, Peter
dc.contributor.author
Peikert, Alexander
dc.contributor.author
Michel, Nathaly Anto
dc.contributor.author
Hergeth, Sonja
dc.contributor.author
Marchini, Timoteo Oscar
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dc.contributor.author
Wolf, Dennis
dc.contributor.author
Dufner, Bianca
dc.contributor.author
Hoppe, Natalie
dc.contributor.author
Ayata, Cemil Korcan
dc.contributor.author
Grimm, Melanie
dc.contributor.author
Cicko, Sanja
dc.contributor.author
Schulte, Lisa
dc.contributor.author
Reinöhl, Jochen
dc.contributor.author
Von Zur Muhlen, Constantin
dc.contributor.author
Bode, Christoph
dc.contributor.author
Idzko, Marco
dc.contributor.author
Zirlik, Andreas
dc.date.available
2018-12-27T14:14:39Z
dc.date.issued
2014-10
dc.identifier.citation
Stachon, Peter; Peikert, Alexander; Michel, Nathaly Anto; Hergeth, Sonja; Marchini, Timoteo Oscar; et al.; P2Y6 deficiency limits vascular inflammation and atherosclerosis in mice; Lippincott Williams; Arteriosclerosis, Thrombosis, and Vascular Biology; 34; 10; 10-2014; 2237-2245
dc.identifier.issn
1079-5642
dc.identifier.uri
http://hdl.handle.net/11336/67036
dc.description.abstract
Objective - Nucleotides such as ATP, ADP, UTP, and UDP serve as proinflammatory danger signals via purinergic receptors on their release to the extracellular space by activated or dying cells. UDP binds to the purinergic receptor Y6 (P2Y6) and propagates vascular inflammation by inducing the expression of chemokines such as monocyte chemoattractant protein 1, interleukin-8, or its mouse homologsCCL1 (chemokine [C-C motif] ligand 1)/keratinocyte chemokine, CXCL2 (chemokine [C-X-C motif] ligand 2)/macrophage inflammatory protein 2, and CXCL5 (chemokine [C-X-C motif] ligand 5)/LIX, and adhesion molecules such as vascular cell adhesion molecule 1 and intercellular cell adhesion molecule 1. Thus, P2Y6 contributes to leukocyte recruitment and inflammation in conditions such as allergic asthma or sepsis. Because atherosclerosis is a chronic inflammatory disease driven by leukocyte recruitment to the vessel wall, we hypothesized a role of P2Y6 in atherogenesis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Lippincott Williams
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Atherosclerosis
dc.subject
Inflammation
dc.subject
P2y6 Receptor
dc.subject
Receptors, Purinergic P2
dc.subject
Uridine Diphosphate
dc.subject
Vascular Cell Adhesion Molecule-1
dc.subject.classification
Medicina Critica y de Emergencia
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
P2Y6 deficiency limits vascular inflammation and atherosclerosis in mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-12-21T15:23:12Z
dc.journal.volume
34
dc.journal.number
10
dc.journal.pagination
2237-2245
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Philadelphia
dc.description.fil
Fil: Stachon, Peter. Universität Freiburg; Alemania
dc.description.fil
Fil: Peikert, Alexander. Universität Freiburg; Alemania
dc.description.fil
Fil: Michel, Nathaly Anto. Universität Freiburg; Alemania
dc.description.fil
Fil: Hergeth, Sonja. Universität Freiburg; Alemania
dc.description.fil
Fil: Marchini, Timoteo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universität Freiburg; Alemania
dc.description.fil
Fil: Wolf, Dennis. Universität Freiburg; Alemania
dc.description.fil
Fil: Dufner, Bianca. Universität Freiburg; Alemania
dc.description.fil
Fil: Hoppe, Natalie. Universität Freiburg; Alemania
dc.description.fil
Fil: Ayata, Cemil Korcan. Universität Freiburg; Alemania
dc.description.fil
Fil: Grimm, Melanie. Universität Freiburg; Alemania
dc.description.fil
Fil: Cicko, Sanja. Universität Freiburg; Alemania
dc.description.fil
Fil: Schulte, Lisa. Universität Freiburg; Alemania
dc.description.fil
Fil: Reinöhl, Jochen. Universität Freiburg; Alemania
dc.description.fil
Fil: Von Zur Muhlen, Constantin. Universität Freiburg; Alemania
dc.description.fil
Fil: Bode, Christoph. Universität Freiburg; Alemania
dc.description.fil
Fil: Idzko, Marco. Universität Freiburg; Alemania
dc.description.fil
Fil: Zirlik, Andreas. Universität Freiburg; Alemania
dc.journal.title
Arteriosclerosis, Thrombosis, and Vascular Biology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1161/ATVBAHA.114.303585
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ahajournals.org/doi/10.1161/ATVBAHA.114.303585
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