Artículo
P2Y6 deficiency limits vascular inflammation and atherosclerosis in mice
Stachon, Peter; Peikert, Alexander; Michel, Nathaly Anto; Hergeth, Sonja; Marchini, Timoteo Oscar
; Wolf, Dennis; Dufner, Bianca; Hoppe, Natalie; Ayata, Cemil Korcan; Grimm, Melanie; Cicko, Sanja; Schulte, Lisa; Reinöhl, Jochen; Von Zur Muhlen, Constantin; Bode, Christoph; Idzko, Marco; Zirlik, Andreas
Fecha de publicación:
10/2014
Editorial:
Lippincott Williams
Revista:
Arteriosclerosis, Thrombosis, and Vascular Biology
ISSN:
1079-5642
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Objective - Nucleotides such as ATP, ADP, UTP, and UDP serve as proinflammatory danger signals via purinergic receptors on their release to the extracellular space by activated or dying cells. UDP binds to the purinergic receptor Y6 (P2Y6) and propagates vascular inflammation by inducing the expression of chemokines such as monocyte chemoattractant protein 1, interleukin-8, or its mouse homologsCCL1 (chemokine [C-C motif] ligand 1)/keratinocyte chemokine, CXCL2 (chemokine [C-X-C motif] ligand 2)/macrophage inflammatory protein 2, and CXCL5 (chemokine [C-X-C motif] ligand 5)/LIX, and adhesion molecules such as vascular cell adhesion molecule 1 and intercellular cell adhesion molecule 1. Thus, P2Y6 contributes to leukocyte recruitment and inflammation in conditions such as allergic asthma or sepsis. Because atherosclerosis is a chronic inflammatory disease driven by leukocyte recruitment to the vessel wall, we hypothesized a role of P2Y6 in atherogenesis.
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Articulos(IBIMOL)
Articulos de INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR
Articulos de INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR
Citación
Stachon, Peter; Peikert, Alexander; Michel, Nathaly Anto; Hergeth, Sonja; Marchini, Timoteo Oscar; et al.; P2Y6 deficiency limits vascular inflammation and atherosclerosis in mice; Lippincott Williams; Arteriosclerosis, Thrombosis, and Vascular Biology; 34; 10; 10-2014; 2237-2245
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