Artículo
Protective action of ppGpp in microcin J25-sensitive strains
Fecha de publicación:
06/2008
Editorial:
American Society for Microbiology
Revista:
Journal of Bacteriology
ISSN:
0021-9193
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
As Escherichia coli strains enter the stationary phase of growth they become more resistant to the peptide antibiotic microcin J25. It is known that starvation for nutrients such as amino acids or glucose leads to increases in guanosine 3′,5′-bispyrophosphate (ppGpp) levels and that the intracellular concentration of this nucleotide increases as cells enter the stationary phase of growth. Therefore, we examined the effects of artificially manipulating the ppGpp levels on sensitivity to microcin J25. A direct correlation was found betweem ppGpp accumulation and microcin resistance. Our results indicate that the nucleotide is required to induce production of YojI, a chromosomally encoded efflux pump which, in turn, expels microcin from cells. This would maintain the intracellular level of the antibiotic below a toxic level.
Palabras clave:
Microcin J25
,
Resistance
,
Ppgpp
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CCT - NOA SUR)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - NOA SUR
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - NOA SUR
Articulos(INSIBIO)
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Citación
Pomares, Maria Fernanda; Vincent, Paula Andrea; Farias, Ricardo Norberto; Salomon, Raul Armando; Protective action of ppGpp in microcin J25-sensitive strains; American Society for Microbiology; Journal of Bacteriology; 190; 12; 6-2008; 4328-4334
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