Artículo

Synthesis and cytotoxic evaluation of four new 6E-hydroximinosteroids

Richmond, VictoriaIcon ; Careaga Quiroga, Valeria PilarIcon ; Sacca, Paula AlejandraIcon ; Calvo, Juan CarlosIcon ; Maier, Marta SilviaIcon
Fecha de publicación: 13/03/2014
Editorial: Elsevier
Revista: Steroids
ISSN: 0039-128X
e-ISSN: 1878-5867
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

Four new 6E-hydroximinosteroids (1, 2a, 3 and 4) have been synthesized from the corresponding ketones, 2β,3β-dihydroxy-5α-cholestan-6-one (5), 2α,3α-dihydroxy-5α-cholestan-6-one (6), 2β,3α-dihydroxy-5α-cholestan-6-one (7) and 2β,3α-dihydroxy-5α-cholestan-6-one-disulfate (8). The cytotoxic activity of the steroidal oximes was evaluated against two prostate carcinoma cell lines (PC-3 and LNCaP) and compared with that of five polyhydroxylated sulfated analogs (8-12). Oxime 3 and trisulfated analog 11 were the most active compounds with IC50 values of 10.8μM (PC-3) and 7.9μM (LNCaP), respectively.
Palabras clave: Hydroximinosteroids , Synthesis , Sulfated Steroids , Prostate Cancer
 
Archivos asociados
Thumbnail
 
Tamaño: 441.9Kb
Formato: PDF
.
Licencia
info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/6577
DOI: http://dx.doi.org/ 10.1016/j.steroids.2014.03.001
DOI: http://dx.doi.org/10.1016/j.steroids.2014.03.001
URL: http://www.sciencedirect.com/science/article/pii/S0039128X14000464
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos(UMYMFOR)
Articulos de UNID.MICROANAL.Y MET.FISICOS EN QUIM.ORG.(I)
Citación
Richmond, Victoria; Careaga Quiroga, Valeria Pilar; Sacca, Paula Alejandra; Calvo, Juan Carlos; Maier, Marta Silvia; Synthesis and cytotoxic evaluation of four new 6E-hydroximinosteroids; Elsevier; Steroids; 84; 13-3-2014; 7-10
Compartir
Altmétricas