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Artículo

Corticosteroid receptors, their chaperones and co-chaperones: How do they modulate adipogenesis?

Toneatto, JudithIcon ; Charó, Nancy LorenaIcon ; Naselli, AgostinaIcon ; Muñoz Bernart, Melina; Lombardi, Antonella; Piwien Pilipuk, GracielaIcon
Fecha de publicación: 05/10/2014
Editorial: Agial Publishing House
Revista: Nuclear Receptor Research
ISSN: 2314-5706
e-ISSN: 2314-5714
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular

Resumen

It is well known that glucocorticoids and mineralocorticoids are part of the list of hormones that control adipogenesis as well as different aspects of the physiology of the adipose tissue. Their actions are mediated through their binding to the glucocorticoid and the mineralocorticoid receptors (GR and MR, respectively), in complex with heat shock proteins (Hsps) and high molecular weight immunophilins (IMMs). Albeit many aspects of the molecular mechanism of the corticosteroid receptors are not fully elucidated yet, it was not until recently that the first evidences of the functional importance of Hsps and IMMs in the process of adipocyte differentiation have been described. Hsp90 and the high molecular weight IMM FKBP51 modulate GR and MR activity at multiple levels, that is, hormone binding affinity, their subcellular distribution, and the transcriptional status, among other aspects of the NR function. Interestingly, it has recently been described that Hsp90 and FKBP51 also participate in the control of PPARγ, a key transcription factor in the control of adipogenesis and the maintenance of the adipocyte phenotype. In addition, novel roles have been uncovered for FKBP51 in the organization of the nuclear architecture through its participation in the reorganization of the nuclear lamina and the control of the subnuclear distribution of GR. Thus, the aim of this review is to integrate and discuss the actual understanding of the role of corticosteroid receptors, their chaperones and cochaperones, in the process of adipocyte differentiation.
Palabras clave: Adipogenesis , Glucocorticoid Receptor , Mineralocorticoid Receptor , Fkbp51
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/6576
DOI: http://dx.doi.org/ 10.11131/2014/101092
URL: http://www.agialpress.com/journals/nurr/2014/101092/
DOI: http://dx.doi.org/10.11131/2014/101092
URL: https://doaj.org/article/22c47279e4e547ffbcaa9deaae4f4fc5
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Toneatto, Judith; Charó, Nancy Lorena; Naselli, Agostina; Muñoz Bernart, Melina; Lombardi, Antonella; et al.; Corticosteroid receptors, their chaperones and co-chaperones: How do they modulate adipogenesis?; Agial Publishing House; Nuclear Receptor Research; 1; 5-10-2014; 1-17
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