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dc.contributor.author
Andino Pavlovsky, Victoria
dc.contributor.author
Souza, Annie C.
dc.contributor.author
Scheffer Teixeira, Robson
dc.contributor.author
Tort, Adriano B. L.
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Etchenique, Roberto Argentino
dc.contributor.author
Ribeiro, Sidarta
dc.date.available
2018-12-04T18:10:11Z
dc.date.issued
2017-05
dc.identifier.citation
Andino Pavlovsky, Victoria; Souza, Annie C.; Scheffer Teixeira, Robson; Tort, Adriano B. L.; Etchenique, Roberto Argentino; et al.; Dopamine Modulates Delta-Gamma Phase-Amplitude Coupling in the Prefrontal Cortex of Behaving Rats; Frontiers in Bioscience; Frontiers in Neural Circuits; 11; 5-2017; 1-13
dc.identifier.issn
1662-5110
dc.identifier.uri
http://hdl.handle.net/11336/65743
dc.description.abstract
Dopamine release and phase-amplitude cross-frequency coupling (CFC) have independently been implicated in prefrontal cortex (PFC) functioning. To causally investigate whether dopamine release affects phase-amplitude comodulation between different frequencies in local field potentials (LFP) recorded from the medial PFC (mPFC) of behaving rats, we used RuBiDopa, a light-sensitive caged compound that releases the neurotransmitter dopamine when irradiated with visible light. LFP power did not change in any frequency band after the application of light-uncaged dopamine, but significantly strengthened phase-amplitude comodulation between delta and gamma oscillations. Saline did not exert significant changes, while injections of dopamine and RuBiDopa produced a slow increase in comodulation for several minutes after the injection. The results show that dopamine release in the medial PFC shifts phase-amplitude comodulation from theta-gamma to delta-gamma. Although being preliminary results due to the limitation of the low number of animals present in this study, our findings suggest that dopamine-mediated modification of the frequencies involved in comodulation could be a mechanism by which this neurotransmitter regulates functioning in mPFC.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers in Bioscience
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Comodulation
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Delta-Gamma Coupling
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Dopamine
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Lfp Oscillation
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Uncaging
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Dopamine Modulates Delta-Gamma Phase-Amplitude Coupling in the Prefrontal Cortex of Behaving Rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-10-23T18:24:20Z
dc.journal.volume
11
dc.journal.pagination
1-13
dc.journal.pais
Suiza
dc.journal.ciudad
Lausana
dc.description.fil
Fil: Andino Pavlovsky, Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Inorgánica, Analítica y Química Física; Argentina
dc.description.fil
Fil: Souza, Annie C.. Universidade Federal do Rio Grande do Norte; Brasil
dc.description.fil
Fil: Scheffer Teixeira, Robson. Universidade Federal do Rio Grande do Norte; Brasil
dc.description.fil
Fil: Tort, Adriano B. L.. Universidade Federal do Rio Grande do Norte; Brasil
dc.description.fil
Fil: Etchenique, Roberto Argentino. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Inorgánica, Analítica y Química Física; Argentina
dc.description.fil
Fil: Ribeiro, Sidarta. Universidade Federal do Rio Grande do Norte; Brasil
dc.journal.title
Frontiers in Neural Circuits
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/article/10.3389/fncir.2017.00029/full
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fncir.2017.00029
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