Artículo
Dopamine Modulates Delta-Gamma Phase-Amplitude Coupling in the Prefrontal Cortex of Behaving Rats
Andino Pavlovsky, Victoria
; Souza, Annie C.; Scheffer Teixeira, Robson; Tort, Adriano B. L.; Etchenique, Roberto Argentino
; Ribeiro, Sidarta


Fecha de publicación:
05/2017
Editorial:
Frontiers in Bioscience
Revista:
Frontiers in Neural Circuits
ISSN:
1662-5110
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Resumen
Dopamine release and phase-amplitude cross-frequency coupling (CFC) have independently been implicated in prefrontal cortex (PFC) functioning. To causally investigate whether dopamine release affects phase-amplitude comodulation between different frequencies in local field potentials (LFP) recorded from the medial PFC (mPFC) of behaving rats, we used RuBiDopa, a light-sensitive caged compound that releases the neurotransmitter dopamine when irradiated with visible light. LFP power did not change in any frequency band after the application of light-uncaged dopamine, but significantly strengthened phase-amplitude comodulation between delta and gamma oscillations. Saline did not exert significant changes, while injections of dopamine and RuBiDopa produced a slow increase in comodulation for several minutes after the injection. The results show that dopamine release in the medial PFC shifts phase-amplitude comodulation from theta-gamma to delta-gamma. Although being preliminary results due to the limitation of the low number of animals present in this study, our findings suggest that dopamine-mediated modification of the frequencies involved in comodulation could be a mechanism by which this neurotransmitter regulates functioning in mPFC.
Archivos asociados
http://journal.frontiersin.org/article/10.3389/fncir.2017.00029/full
http://dx.doi.org/10.3389/fncir.2017.00029
http://dx.doi.org/10.3389/fncir.2017.00029

Citación:
Andino Pavlovsky, Victoria; Souza, Annie C.; Scheffer Teixeira, Robson; Tort, Adriano B. L.; Etchenique, Roberto Argentino; et al.; Dopamine Modulates Delta-Gamma Phase-Amplitude Coupling in the Prefrontal Cortex of Behaving Rats; Frontiers in Bioscience; Frontiers in Neural Circuits; 11; 5-2017; 1-13
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Articulos(INQUIMAE) [807]
Articulos de INST.D/QUIM FIS D/L MATERIALES MEDIOAMB Y ENERGIA