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Artículo

Antigenic and immunogenic spectrum of foot and mouth disease vaccine strain O1 Campos against representative viruses of topotypes that circulated in Asia over the past decade

Galdo Novo, Sabrina; Malirat, VivianaIcon ; Maradei, Eduardo D.; Espinoza, Ana María; Smitsaart, Eliana; Pedemonte, Andrea; Mattion, Nora MartaIcon ; Bergmann, Ingrid EvelynIcon
Fecha de publicación: 04/2017
Editorial: Elsevier
Revista: Vaccine
ISSN: 0264-410X
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Biológicas

Resumen

Identifying vaccine strains to control outbreaks of foot-and-mouth disease virus that could spread to new regions is essential for contingency plans. This is the first report on the antigenic/immunogenic relationships of the South American O1/Campos vaccine strain with representative isolates of the three currently active Asian type O topotypes. Virus neutralization tests using O1/Campos post-vaccination sera derived from cattle and pigs predicted for both species acceptable cross-protection, even after single vaccination, established by r1 values and by expectancy of protection using monovalent or polyvalent vaccines. The results indicate that effective oil vaccines containing the O1/Campos strain can be used against Asian isolates, expanding the scope of O1/Campos strain included in vaccine banks to control emergencies caused by Asian viruses, even on single-dose vaccination, and to cover the need of effective vaccines in Asia during systematic vaccination.
Palabras clave: Foot-And-Mouth Disease , Vaccine Matching
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/64111
DOI: http://dx.doi.org/10.1016/j.vaccine.2017.03.026
URL: https://www.sciencedirect.com/science/article/pii/S0264410X17303328
Colecciones
Articulos(ICT - MILSTEIN)
Articulos de INST.DE CS. Y TECNOLOGIA "DR. CESAR MILSTEIN"
Citación
Galdo Novo, Sabrina; Malirat, Viviana; Maradei, Eduardo D.; Espinoza, Ana María; Smitsaart, Eliana; et al.; Antigenic and immunogenic spectrum of foot and mouth disease vaccine strain O1 Campos against representative viruses of topotypes that circulated in Asia over the past decade; Elsevier; Vaccine; 35; 18; 4-2017; 2303-2307
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