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dc.contributor.author
Thome, Alexander
dc.contributor.author
Marrone, Diano F.
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Ellmore, Timothy M.
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Chawla, Monica K.
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Lipa, Peter
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Ramirez Amaya, Victor
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Lisanby, Sarah H.
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McNaughton, Bruce L.
dc.contributor.author
Barnes, Carol A.
dc.date.available
2018-11-09T13:25:11Z
dc.date.issued
2017-03-07
dc.identifier.citation
Thome, Alexander; Marrone, Diano F.; Ellmore, Timothy M.; Chawla, Monica K.; Lipa, Peter; et al.; Evidence for an evolutionarily conserved memory coding scheme in the mammalian hippocampus; Society for Neuroscience; Journal of Neuroscience; 37; 10; 7-3-2017; 2795-2801
dc.identifier.issn
0270-6474
dc.identifier.uri
http://hdl.handle.net/11336/64055
dc.description.abstract
Decades of research identify the hippocampal formation as central to memory storage and recall. Events are stored via distributed population codes, the parameters of which (e.g., sparsity and overlap) determine both storage capacity and fidelity. However, it remains unclear whether the parameters governing information storage are similar between species. Because episodic memories are rooted in the space in which they are experienced, the hippocampal response to navigation is often used as a proxy to study memory. Critically, recent studies in rodents that mimic the conditions typical of navigation studies in humans and nonhuman primates (i.e., virtual reality) show that reduced sensory input alters hippocampal representations of space. The goal of this study was to quantify this effect and determine whether there are commonalities in information storage across species. Using functional molecular imaging, we observe that navigation in virtual environments elicits activity in fewer CA1 neurons relative to real-world conditions. Conversely, comparable neuronal activity is observed in hippocampus region CA3 and the dentate gyrus under both conditions. Surprisingly, we also find evidence that the absolute number of neurons used to represent an experience is relatively stable between nonhuman primates and rodents. We propose that this convergence reflects an optimal ensemble size for episodic memories.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Society for Neuroscience
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Neural Coding
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Neuroethology
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Primate
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Rodent
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Spatial Cognition
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Virtual Reality
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Evidence for an evolutionarily conserved memory coding scheme in the mammalian hippocampus
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-10-22T15:50:42Z
dc.identifier.eissn
1529-2401
dc.journal.volume
37
dc.journal.number
10
dc.journal.pagination
2795-2801
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Thome, Alexander. University of Arizona; Estados Unidos
dc.description.fil
Fil: Marrone, Diano F.. University of Arizona; Estados Unidos. Wilfrid Laurier University; Canadá
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Fil: Ellmore, Timothy M.. The City College of New York; Estados Unidos
dc.description.fil
Fil: Chawla, Monica K.. University of Arizona; Estados Unidos
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Fil: Lipa, Peter. University of Arizona; Estados Unidos
dc.description.fil
Fil: Ramirez Amaya, Victor. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Autónoma de Queretaro; México
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Fil: Lisanby, Sarah H.. University of Duke; Estados Unidos
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Fil: McNaughton, Bruce L.. The University of Lethbridge; Canadá. University of California at Irvine; Estados Unidos
dc.description.fil
Fil: Barnes, Carol A.. University of Arizona; Estados Unidos
dc.journal.title
Journal of Neuroscience
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1523/JNEUROSCI.3057-16.2017
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.jneurosci.org/content/37/10/2795
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