Artículo
Evidence for an evolutionarily conserved memory coding scheme in the mammalian hippocampus
Thome, Alexander; Marrone, Diano F.; Ellmore, Timothy M.; Chawla, Monica K.; Lipa, Peter; Ramirez Amaya, Victor
; Lisanby, Sarah H.; McNaughton, Bruce L.; Barnes, Carol A.
Fecha de publicación:
07/03/2017
Editorial:
Society for Neuroscience
Revista:
Journal of Neuroscience
ISSN:
0270-6474
e-ISSN:
1529-2401
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Decades of research identify the hippocampal formation as central to memory storage and recall. Events are stored via distributed population codes, the parameters of which (e.g., sparsity and overlap) determine both storage capacity and fidelity. However, it remains unclear whether the parameters governing information storage are similar between species. Because episodic memories are rooted in the space in which they are experienced, the hippocampal response to navigation is often used as a proxy to study memory. Critically, recent studies in rodents that mimic the conditions typical of navigation studies in humans and nonhuman primates (i.e., virtual reality) show that reduced sensory input alters hippocampal representations of space. The goal of this study was to quantify this effect and determine whether there are commonalities in information storage across species. Using functional molecular imaging, we observe that navigation in virtual environments elicits activity in fewer CA1 neurons relative to real-world conditions. Conversely, comparable neuronal activity is observed in hippocampus region CA3 and the dentate gyrus under both conditions. Surprisingly, we also find evidence that the absolute number of neurons used to represent an experience is relatively stable between nonhuman primates and rodents. We propose that this convergence reflects an optimal ensemble size for episodic memories.
Palabras clave:
Neural Coding
,
Neuroethology
,
Primate
,
Rodent
,
Spatial Cognition
,
Virtual Reality
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(INIMEC - CONICET)
Articulos de INSTITUTO DE INV. MEDICAS MERCEDES Y MARTIN FERREYRA
Articulos de INSTITUTO DE INV. MEDICAS MERCEDES Y MARTIN FERREYRA
Citación
Thome, Alexander; Marrone, Diano F.; Ellmore, Timothy M.; Chawla, Monica K.; Lipa, Peter; et al.; Evidence for an evolutionarily conserved memory coding scheme in the mammalian hippocampus; Society for Neuroscience; Journal of Neuroscience; 37; 10; 7-3-2017; 2795-2801
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