Artículo
Subclinical lower airways correlates of chronic allergic and non-allergic rhinitis
Fecha de publicación:
19/08/2017
Editorial:
Wiley Blackwell Publishing, Inc
Revista:
Clinical And Experimental Allergy
ISSN:
0954-7894
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The upper and lower airways behave as a physiological and pathophysiological unit. Subclinical lower airways abnormalities have been described in patients with rhinitis without asthma. These are expressed as bronchial hyperreactivity, abnormalities in lung function and bronchial inflammation, likely as a result of the same phenomenon with systemic inflammatory impact that reaches both the nose and the lungs, which for unknown reasons does not always have a full clinical expression. Patients with rhinitis are at increased risk of developing asthma; therefore, most authors suggest a careful clinical evaluation and monitoring of these patients, especially if symptoms related to inflammation in the lower airways are observed. Although current treatments, such as H1-antihistamines, intranasal steroids and allergen immunotherapy, are quite effective for the management of rhinitis, it is difficult to prove their capacity to prevent asthma among subjects with rhinitis. Evidence showing that the treatment of rhinitis has a favourable impact on indicators of bronchial hyperreactivity and inflammation among subjects that have no symptoms of asthma is more frequently described. In this review, we address the frequency and characteristics of lower airway abnormalities in subjects with rhinitis, both in paediatric and adult populations, their likely predictive value for the development of asthma and the possibilities for therapeutic intervention that could modify the risk of subjects with rhinitis towards presenting asthma.
Palabras clave:
Allergic Rinitis
,
Spirometry
,
Feno
,
Non-Allergic Rhinitis
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(INICSA)
Articulos de INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
Articulos de INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
Citación
Saranz, R.J.; Lozano, A.; Lozano, N.A.; Ponzio, Marina Flavia; Cruz, Á. A.; Subclinical lower airways correlates of chronic allergic and non-allergic rhinitis; Wiley Blackwell Publishing, Inc; Clinical And Experimental Allergy; 47; 8; 19-8-2017; 988-997
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