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dc.contributor.author
Scotti, Leopoldina
dc.contributor.author
Abramovich, Dalhia Nurit
dc.contributor.author
Pascuali, Natalia Marisa
dc.contributor.author
Irusta, Griselda
dc.contributor.author
Meresman, Gabriela Fabiana
dc.contributor.author
Tesone, Marta
dc.contributor.author
Parborell, Maria Fernanda Agustina
dc.date.available
2016-07-05T20:50:31Z
dc.date.issued
2014-08
dc.identifier.citation
Scotti, Leopoldina; Abramovich, Dalhia Nurit; Pascuali, Natalia Marisa; Irusta, Griselda; Meresman, Gabriela Fabiana; et al.; Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome.; Elsevier; Journal of Steroid Biochemistry and Molecular Biology; 144; Part B; 8-2014; 392-401
dc.identifier.issn
0960-0760
dc.identifier.uri
http://hdl.handle.net/11336/6375
dc.description.abstract
The relationship between human chorionic gonadotropin and ovarian hyperstimulation syndrome (OHSS) is partially mediated by vascular endothelial growth factor A (VEGF). The aim of this study was to investigate the effects of VEGF inhibition on the development of corpora lutea (CL) and cystic structures, steroidogenesis, apoptosis, cell proliferation, endothelial cell area, VEGF receptors (KDR and Flt-1), claudin-5 and occludin levels in ovaries from an OHSS rat model. The VEGF inhibitor used (VEGF receptor-1 (FLT-1)/Fc chimera, TRAP) decreased the concentrations of progesterone and estradiol as well as the percentage of CL and cystic structures in OHSS rats, and increased apoptosis in CL. Endothelial cell area in CL and KDR expression and its phosphorylation were increased, whereas claudin-5 and occludin levels were decreased in the OHSS compared to the control TRAP reversed these parameters. Our findings indicate that VEGF inhibition prevents the early onset of OHSS and decreases its severity in rats.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Ovarian Htyperstimulation Syndrome
dc.subject
Vegf
dc.subject
Apoptosis Drug Effects
dc.subject
Corporea Lutea
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Occludin Metabolism
dc.subject.classification
Bioquímica y Biología Molecular
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Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome.
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-06-15T19:11:01Z
dc.identifier.eissn
1879-1220
dc.journal.volume
144
dc.journal.number
Part B
dc.journal.pagination
392-401
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Scotti, Leopoldina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil
Fil: Abramovich, Dalhia Nurit. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil
Fil: Pascuali, Natalia Marisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil
Fil: Irusta, Griselda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil
Fil: Meresman, Gabriela Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil
Fil: Tesone, Marta. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil
Fil: Parborell, Maria Fernanda Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.journal.title
Journal of Steroid Biochemistry and Molecular Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jsbmb.2014.08.013
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jsbmb.2014.08.013
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0960076014001927


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