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dc.contributor.author Scotti, Leopoldina
dc.contributor.author Abramovich, Dalhia Nurit
dc.contributor.author Pascuali, Natalia Marisa
dc.contributor.author Irusta, Griselda
dc.contributor.author Meresman, Gabriela Fabiana
dc.contributor.author Tesone, Marta
dc.contributor.author Parborell, Maria Fernanda Agustina
dc.date.available 2016-07-05T20:50:31Z
dc.date.issued 2014-08
dc.identifier.citation Scotti, Leopoldina; Abramovich, Dalhia Nurit; Pascuali, Natalia Marisa; Irusta, Griselda; Meresman, Gabriela Fabiana; et al.; Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome.; Elsevier; Journal of Steroid Biochemistry and Molecular Biology; 144; Part B; 8-2014; 392-401
dc.identifier.issn 0960-0760
dc.identifier.uri http://hdl.handle.net/11336/6375
dc.description.abstract The relationship between human chorionic gonadotropin and ovarian hyperstimulation syndrome (OHSS) is partially mediated by vascular endothelial growth factor A (VEGF). The aim of this study was to investigate the effects of VEGF inhibition on the development of corpora lutea (CL) and cystic structures, steroidogenesis, apoptosis, cell proliferation, endothelial cell area, VEGF receptors (KDR and Flt-1), claudin-5 and occludin levels in ovaries from an OHSS rat model. The VEGF inhibitor used (VEGF receptor-1 (FLT-1)/Fc chimera, TRAP) decreased the concentrations of progesterone and estradiol as well as the percentage of CL and cystic structures in OHSS rats, and increased apoptosis in CL. Endothelial cell area in CL and KDR expression and its phosphorylation were increased, whereas claudin-5 and occludin levels were decreased in the OHSS compared to the control TRAP reversed these parameters. Our findings indicate that VEGF inhibition prevents the early onset of OHSS and decreases its severity in rats.
dc.format application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject OVARIAN HTYPERSTIMULATION SYNDROME
dc.subject VEGF
dc.subject APOPTOSIS DRUG EFFECTS
dc.subject CORPOREA LUTEA
dc.subject OCCLUDIN METABOLISM
dc.subject.classification Bioquímica y Biología Molecular
dc.subject.classification Ciencias Biológicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome.
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2016-06-15T19:11:01Z
dc.identifier.eissn 1879-1220
dc.journal.volume 144
dc.journal.number Part B
dc.journal.pagination 392-401
dc.journal.pais Países Bajos
dc.journal.ciudad Amsterdam
dc.description.fil Fil: Scotti, Leopoldina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil Fil: Abramovich, Dalhia Nurit. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil Fil: Pascuali, Natalia Marisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil Fil: Irusta, Griselda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil Fil: Meresman, Gabriela Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil Fil: Tesone, Marta. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil Fil: Parborell, Maria Fernanda Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.journal.title Journal of Steroid Biochemistry and Molecular Biology
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jsbmb.2014.08.013
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jsbmb.2014.08.013
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0960076014001927


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)