Artículo
Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome.
Scotti, Leopoldina
; Abramovich, Dalhia Nurit
; Pascuali, Natalia Marisa
; Irusta, Griselda
; Meresman, Gabriela Fabiana
; Tesone, Marta
; Parborell, Maria Fernanda Agustina
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Fecha de publicación:
08/2014
Editorial:
Elsevier
Revista:
Journal of Steroid Biochemistry and Molecular Biology
ISSN:
0960-0760
e-ISSN:
1879-1220
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The relationship between human chorionic gonadotropin and ovarian hyperstimulation syndrome (OHSS) is partially mediated by vascular endothelial growth factor A (VEGF). The aim of this study was to investigate the effects of VEGF inhibition on the development of corpora lutea (CL) and cystic structures, steroidogenesis, apoptosis, cell proliferation, endothelial cell area, VEGF receptors (KDR and Flt-1), claudin-5 and occludin levels in ovaries from an OHSS rat model. The VEGF inhibitor used (VEGF receptor-1 (FLT-1)/Fc chimera, TRAP) decreased the concentrations of progesterone and estradiol as well as the percentage of CL and cystic structures in OHSS rats, and increased apoptosis in CL. Endothelial cell area in CL and KDR expression and its phosphorylation were increased, whereas claudin-5 and occludin levels were decreased in the OHSS compared to the control TRAP reversed these parameters. Our findings indicate that VEGF inhibition prevents the early onset of OHSS and decreases its severity in rats.
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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos(OCA CIUDAD UNIVERSITARIA)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA CIUDAD UNIVERSITARIA
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA CIUDAD UNIVERSITARIA
Citación
Scotti, Leopoldina; Abramovich, Dalhia Nurit; Pascuali, Natalia Marisa; Irusta, Griselda; Meresman, Gabriela Fabiana; et al.; Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome.; Elsevier; Journal of Steroid Biochemistry and Molecular Biology; 144; Part B; 8-2014; 392-401
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