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dc.contributor.author Massillo, Cintia Lorena
dc.contributor.author Dalton, Guillermo Nicolás
dc.contributor.author Farré, Paula Lucía
dc.contributor.author de Luca, Paola
dc.contributor.author de Siervi, Adriana
dc.date.available 2018-10-25T16:07:11Z
dc.date.issued 2017-10
dc.identifier.citation Massillo, Cintia Lorena; Dalton, Guillermo Nicolás; Farré, Paula Lucía; de Luca, Paola; de Siervi, Adriana; Implications of microRNA dysregulation in the development of prostate cancer; BioScientifica; Reproduction; 154; 4; 10-2017; R81-R97
dc.identifier.issn 1470-1626
dc.identifier.uri http://hdl.handle.net/11336/63050
dc.description.abstract MicroRNAs (miRNAs) are non-coding small RNAs that target mRNA to reduce protein expression. They play fundamental roles in several diseases, including prostate cancer (PCa). A single miRNA can target hundreds of mRNAs and coordinately regulate them, which implicates them in nearly every biological pathway. Hence, miRNAs modulates proliferation, cell cycle, apoptosis, adhesion, migration, invasion and metastasis, most of them constituting crucial hallmarks of cancer. Due to these properties, miRNAs emerged as promising tools for diagnostic, prognosis and management of cancer patients. Moreover, they come out as potential targets for cancer treatment and several efforts are being made to progress in the field of miRNA-based cancer therapy. In this review we will summarize the recent information about miRNAs in PCa. We will recapitulate all the miRNAs involved in the androgen pathway and the biology of PCa, focusing in PCa initiation and progression. In particular, we will describe the miRNAs associated with cell proliferation, cell cycle and apoptosis in PCa, as well as invasion, adhesion and metastatic miRNAs. We will revise the recent progress made understanding the role of circulating miRNAs identified in PCa that might be useful for PCa patient stratification. Another key aspect to be discussed in this review is miRNA role in PCa therapy, including miRNAs delivery.
dc.format application/pdf
dc.language.iso eng
dc.publisher BioScientifica
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject microRNA
dc.subject PROSTATE CANCER
dc.subject METASTASIS
dc.subject ANDROGEN RECEPTOR
dc.subject.classification Inmunología
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Implications of microRNA dysregulation in the development of prostate cancer
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-10-23T15:50:54Z
dc.journal.volume 154
dc.journal.number 4
dc.journal.pagination R81-R97
dc.journal.pais Reino Unido
dc.journal.ciudad Bristol
dc.description.fil Fil: Massillo, Cintia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil Fil: Dalton, Guillermo Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil Fil: Farré, Paula Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil Fil: de Luca, Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil Fil: de Siervi, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.journal.title Reproduction
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://rep.bioscientifica.com/view/journals/rep/154/4/REP-17-0322.xml
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1530/REP-17-0322
dc.conicet.fuente individual


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)