Artículo
Implications of microRNA dysregulation in the development of prostate cancer
Massillo, Cintia Lorena
; Dalton, Guillermo Nicolás
; Farré, Paula Lucía
; de Luca, Paola
; de Siervi, Adriana
Fecha de publicación:
10/2017
Editorial:
BioScientifica
Revista:
Reproduction
ISSN:
1470-1626
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
MicroRNAs (miRNAs) are non-coding small RNAs that target mRNA to reduce protein expression. They play fundamental roles in several diseases, including prostate cancer (PCa). A single miRNA can target hundreds of mRNAs and coordinately regulate them, which implicates them in nearly every biological pathway. Hence, miRNAs modulates proliferation, cell cycle, apoptosis, adhesion, migration, invasion and metastasis, most of them constituting crucial hallmarks of cancer. Due to these properties, miRNAs emerged as promising tools for diagnostic, prognosis and management of cancer patients. Moreover, they come out as potential targets for cancer treatment and several efforts are being made to progress in the field of miRNA-based cancer therapy. In this review we will summarize the recent information about miRNAs in PCa. We will recapitulate all the miRNAs involved in the androgen pathway and the biology of PCa, focusing in PCa initiation and progression. In particular, we will describe the miRNAs associated with cell proliferation, cell cycle and apoptosis in PCa, as well as invasion, adhesion and metastatic miRNAs. We will revise the recent progress made understanding the role of circulating miRNAs identified in PCa that might be useful for PCa patient stratification. Another key aspect to be discussed in this review is miRNA role in PCa therapy, including miRNAs delivery.
Palabras clave:
Microrna
,
Prostate Cancer
,
Metastasis
,
Androgen Receptor
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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Massillo, Cintia Lorena; Dalton, Guillermo Nicolás; Farré, Paula Lucía; de Luca, Paola; de Siervi, Adriana; Implications of microRNA dysregulation in the development of prostate cancer; BioScientifica; Reproduction; 154; 4; 10-2017; R81-R97
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