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dc.contributor.author
Gonzalez, Betina
dc.contributor.author
Ratner, Laura Daniela
dc.contributor.author
Scerbo Jaureguiberry, Maria Julia
dc.contributor.author
Di Giorgio, Noelia Paula
dc.contributor.author
Poutanen, Matti
dc.contributor.author
Huhtaniemi, Ilpo T.
dc.contributor.author
Calandra, Ricardo Saul
dc.contributor.author
Lux, Victoria Adela R.
dc.contributor.author
Cambiasso, Maria Julia
dc.contributor.author
Rulli, Susana Beatriz
dc.date.available
2016-07-01T15:54:04Z
dc.date.issued
2014-06-05
dc.identifier.citation
Gonzalez, Betina; Ratner, Laura Daniela; Scerbo Jaureguiberry, Maria Julia; Di Giorgio, Noelia Paula; Poutanen, Matti ; et al.; Elevated hypothalamic aromatization at the onset of precocious puberty in transgenic female mice hypersecreting human chorionic gonadotropin: effect of androgens; Elsevier Ireland; Molecular and Cellular Endocrinology; 390; 1-2; 5-6-2014; 102-111
dc.identifier.issn
0303-7207
dc.identifier.uri
http://hdl.handle.net/11336/6286
dc.description.abstract
Transgenic female mice overexpressing the α- and β- subunits of human chorionic gonadotropin (hCGαβ+) exhibited precocious puberty, as evidenced by early vaginal opening. Chronically elevated hCG in 21-day-old hCGαβ+ females stimulated gonadal androgen production, which exerted negative feedback over the endogenous gonadotropin synthesis, and activated the hypothalamic GnRH pulsatility and gene expression. Transgenic females also exhibited elevated hypothalamic aromatization in the preoptic area (POA), which is the sexually-differentiated area that controls the LH surge in adulthood. Ovariectomy at 14days of age was unable to rescue this phenotype. However, the blockade of androgen action by flutamide from postnatal day 6 onwards reduced the aromatase levels in the POA of hCGαβ+ females. Our results suggest that early exposure of females to androgen action during a critical period between postnatal days 6-14 induces sex-specific organizational changes of the brain, which affect the aromatase expression in the POA at the onset of precocious puberty.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Ireland
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Aromatase
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Human Corionic Gonadotropin
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Hypothalamic-Pituitary-Gonadal Axis
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Precocious Puberty
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Transgenic Mice
dc.subject.classification
Bioquímica y Biología Molecular
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Elevated hypothalamic aromatization at the onset of precocious puberty in transgenic female mice hypersecreting human chorionic gonadotropin: effect of androgens
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-06-15T19:12:38Z
dc.identifier.eissn
1872-8057
dc.journal.volume
390
dc.journal.number
1-2
dc.journal.pagination
102-111
dc.journal.pais
Irlanda
dc.journal.ciudad
Limerick
dc.description.fil
Fil: Gonzalez, Betina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil
Fil: Ratner, Laura Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil
Fil: Scerbo Jaureguiberry, Maria Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Conicet - Córdoba. Instituto de Investigaciones Médicas Mercedes y Martín Ferreyra; Argentina
dc.description.fil
Fil: Di Giorgio, Noelia Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil
Fil: Poutanen, Matti . University of Turku; Finlandia
dc.description.fil
Fil: Huhtaniemi, Ilpo T.. University of Turku; Finlandia. Imperial College London; Reino Unido
dc.description.fil
Fil: Calandra, Ricardo Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil
Fil: Lux, Victoria Adela R.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil
Fil: Cambiasso, Maria Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Investigaciones Médicas Mercedes y Martín Ferreyra; Argentina
dc.description.fil
Fil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.journal.title
Molecular and Cellular Endocrinology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.mce.2014.04.005
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/ark/10.1016/j.mce.2014.04.005
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0303720714001233
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