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Artículo

Elevated hypothalamic aromatization at the onset of precocious puberty in transgenic female mice hypersecreting human chorionic gonadotropin: effect of androgens

Gonzalez, BetinaIcon ; Ratner, Laura DanielaIcon ; Scerbo Jaureguiberry, Maria JuliaIcon ; Di Giorgio, Noelia PaulaIcon ; Poutanen, Matti ; Huhtaniemi, Ilpo T.; Calandra, Ricardo SaulIcon ; Lux, Victoria Adela R.Icon ; Cambiasso, Maria JuliaIcon ; Rulli, Susana BeatrizIcon
Fecha de publicación: 05/06/2014
Editorial: Elsevier Ireland
Revista: Molecular and Cellular Endocrinology
ISSN: 0303-7207
e-ISSN: 1872-8057
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular

Resumen

Transgenic female mice overexpressing the α- and β- subunits of human chorionic gonadotropin (hCGαβ+) exhibited precocious puberty, as evidenced by early vaginal opening. Chronically elevated hCG in 21-day-old hCGαβ+ females stimulated gonadal androgen production, which exerted negative feedback over the endogenous gonadotropin synthesis, and activated the hypothalamic GnRH pulsatility and gene expression. Transgenic females also exhibited elevated hypothalamic aromatization in the preoptic area (POA), which is the sexually-differentiated area that controls the LH surge in adulthood. Ovariectomy at 14days of age was unable to rescue this phenotype. However, the blockade of androgen action by flutamide from postnatal day 6 onwards reduced the aromatase levels in the POA of hCGαβ+ females. Our results suggest that early exposure of females to androgen action during a critical period between postnatal days 6-14 induces sex-specific organizational changes of the brain, which affect the aromatase expression in the POA at the onset of precocious puberty.
Palabras clave: Aromatase , Human Corionic Gonadotropin , Hypothalamic-Pituitary-Gonadal Axis , Precocious Puberty , Transgenic Mice
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/6286
DOI: http://dx.doi.org/10.1016/j.mce.2014.04.005
URL: http://www.sciencedirect.com/science/article/pii/S0303720714001233
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos(INIMEC - CONICET)
Articulos de INSTITUTO DE INV. MEDICAS MERCEDES Y MARTIN FERREYRA
Citación
Gonzalez, Betina; Ratner, Laura Daniela; Scerbo Jaureguiberry, Maria Julia; Di Giorgio, Noelia Paula; Poutanen, Matti ; et al.; Elevated hypothalamic aromatization at the onset of precocious puberty in transgenic female mice hypersecreting human chorionic gonadotropin: effect of androgens; Elsevier Ireland; Molecular and Cellular Endocrinology; 390; 1-2; 5-6-2014; 102-111
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