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dc.contributor.author
Costa, L. M.
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de Macedo, E. V.
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Oliveira, F. A. A.
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Ferreira, J. H. L.
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Gutierrez, S. J. C.
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Peláez, Walter José
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Lima, F. C. A.
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Siqueira Jr, J. P.
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Coutinho, H. D. M.
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Kaatz, G. W.
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de Freitas, R. M.
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Barreto, H. M.
dc.date.available
2018-10-09T21:44:27Z
dc.date.issued
2016-11-18
dc.identifier.citation
Costa, L. M.; de Macedo, E. V.; Oliveira, F. A. A.; Ferreira, J. H. L.; Gutierrez, S. J. C.; et al.; Inhibition of the NorA efflux pump of Staphylococcus aureus by synthetic riparins; Wiley Blackwell Publishing, Inc; Journal of Applied Microbiology; 121; 5; 18-11-2016; 1312-1322
dc.identifier.issn
1364-5072
dc.identifier.uri
http://hdl.handle.net/11336/62041
dc.description.abstract
Aim: The goal of this study was to increase knowledge about the antimicrobial activity of some synthetic Riparin-derived compounds, alone or in combination with fluoroquinolone antibiotics, against a strain of Staphylococcus aureus resistant to fluoroquinolone by way of overexpression of the NorA efflux pump. Methods and Results: Microdilution tests showed that Riparins A and B did not show any significant antibacterial activity against Staph. aureus strains. On the other hand, the intrinsic antibacterial activity increased with increasing lipophilicity of the compounds, in the following order: Riparin-D (MIC 256 μg ml−1; Log P 2·95) < Riparin-C (MIC 102 μg ml−1; Log P 3·22) < Riparin-E (MIC 16 μg ml−1; Log P 3·57). The addition of all riparins to growth media at subinhibitory concentrations caused an increase in the antibacterial activity of antibiotics against the NorA-overexpressing test strain. Riparin-B, which has two methoxyl groups at the phenethyl moiety, showed the best modulatory effect. Conclusions: Riparin-E is a good anti-staphylococci agent, while Riparin-B functions as a NorA efflux pump inhibitor. Significance and Impact of the Study: Our data suggest the possibility of using Riparin-B in combination with norfloxacin or ciprofloxacin for therapy of infections caused by multi-drug resistant Staph. aureus.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Antibiotics
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Diseases
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Infection
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Resistance
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Staphylococci
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Otras Ciencias Químicas
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Inhibition of the NorA efflux pump of Staphylococcus aureus by synthetic riparins
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-09-10T15:46:29Z
dc.journal.volume
121
dc.journal.number
5
dc.journal.pagination
1312-1322
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Costa, L. M.. Federal University of Piauí; Brasil
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Fil: de Macedo, E. V.. Federal University of Piauí; Brasil
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Fil: Oliveira, F. A. A.. Federal University of Piauí; Brasil
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Fil: Ferreira, J. H. L.. Federal University of Piauí; Brasil
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Fil: Gutierrez, S. J. C.. Federal University of Piauí; Brasil
dc.description.fil
Fil: Peláez, Walter José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
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Fil: Lima, F. C. A.. Federal University of Piauí; Brasil
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Fil: Siqueira Jr, J. P.. Federal University of Paraiba; Brasil
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Fil: Coutinho, H. D. M.. Regional University of Cariri; Brasil
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Fil: Kaatz, G. W.. Wayne State University School of Medicine; Estados Unidos
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Fil: de Freitas, R. M.. Federal University of Piauí; Brasil
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Fil: Barreto, H. M.. Federal University of Piauí; Brasil
dc.journal.title
Journal of Applied Microbiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/jam.13258
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://doi.org/10.1111/jam.13258
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