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dc.contributor.author
Alarcon, Emilio I.
dc.contributor.author
Udekwu, Klas
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Skog, Mårten
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Pacioni, Natalia Lorena
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dc.contributor.author
Stamplecoskie, Kevin G.
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González Béjar, María
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Polisetti, Naresh
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Wickham, Abeni
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Richter Dahlfors, Agneta
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Griffith, May
dc.contributor.author
Scaiano, Juan Cesar
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dc.date.available
2018-10-09T16:34:45Z
dc.date.issued
2012-06
dc.identifier.citation
Alarcon, Emilio I.; Udekwu, Klas; Skog, Mårten; Pacioni, Natalia Lorena; Stamplecoskie, Kevin G.; et al.; The biocompatibility and antibacterial properties of collagen-stabilized, photochemically prepared silver nanoparticles; Elsevier; Biomaterials; 33; 19; 6-2012; 4947-4956
dc.identifier.issn
0142-9612
dc.identifier.uri
http://hdl.handle.net/11336/61963
dc.description.abstract
Spherical 3.5 nm diameter silver nanoparticles (AgNP) stabilized in type I collagen (. AgNP@collagen) were prepared in minutes (5-15 min) at room temperature by a photochemical method initiated by UVA irradiation of a water-soluble non-toxic benzoin. This biocomposite was examined to evaluate its biocompatibility and its anti-bacterial properties and showed remarkable properties. Thus, while keratinocytes and fibroblasts were not affected by . AgNP@collagen, it was bactericidal against . Bacillus megaterium and . E. coli but only bacteriostatic against . S. . epidermidis. In particular, the bactericidal properties displayed by . AgNP@collagen were proven to be due to AgNP in . AgNP@collagen, rather than to released silver ions, since equimolar concentrations of Ag are about four times less active than . AgNP@collagen based on total Ag content. This new biocomposite was stable over a remarkable range of NaCl, phosphate, and 2-(N-morpholino)ethanesulfonic acid concentrations and for over one month at 4 °C. Circular dichroism studies show that the conformation of collagen in . AgNP@collagen remains intact. Finally, we have compared the properties of . AgNP@collagen with a similar biocomposite prepared using α-poly-. l-Lysine and also with citrate stabilized AgNP; neither of these materials showed comparable biocompatibility, stability, or anti-bacterial activity. © 2012 Elsevier Ltd.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Antimicrobial Activity
dc.subject
Cell Toxicity
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Poly-L-Lysine
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Silver Nano Particles
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Type-I Collagen
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Otras Ciencias Químicas
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
The biocompatibility and antibacterial properties of collagen-stabilized, photochemically prepared silver nanoparticles
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-09-18T16:15:13Z
dc.journal.volume
33
dc.journal.number
19
dc.journal.pagination
4947-4956
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Alarcon, Emilio I.. University of Ottawa; Canadá
dc.description.fil
Fil: Udekwu, Klas. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
dc.description.fil
Fil: Skog, Mårten. Linköping University; Suecia
dc.description.fil
Fil: Pacioni, Natalia Lorena. University of Ottawa; Canadá
dc.description.fil
Fil: Stamplecoskie, Kevin G.. University of Ottawa; Canadá
dc.description.fil
Fil: González Béjar, María. University of Ottawa; Canadá
dc.description.fil
Fil: Polisetti, Naresh. Linköping University; Suecia
dc.description.fil
Fil: Wickham, Abeni. Linköping University; Suecia
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Fil: Richter Dahlfors, Agneta. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
dc.description.fil
Fil: Griffith, May. Linköping University; Suecia. University of Ottawa Eye Institute; Canadá
dc.description.fil
Fil: Scaiano, Juan Cesar. University of Ottawa; Canadá. Linköping University; Suecia
dc.journal.title
Biomaterials
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.biomaterials.2012.03.033
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0142961212003201
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