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dc.contributor.author
Kivlehan, Francine
dc.contributor.author
Garay, Fernando Sebastian
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dc.contributor.author
Guo, Jidong
dc.contributor.author
Chaum, Edward
dc.contributor.author
Lindner, Ernö
dc.date.available
2018-10-09T16:34:25Z
dc.date.issued
2012-09
dc.identifier.citation
Kivlehan, Francine; Garay, Fernando Sebastian; Guo, Jidong; Chaum, Edward; Lindner, Ernö; Toward feedback-controlled anesthesia: Voltammetric measurement of propofol (2,6-diisopropylphenol) in serum-like electrolyte solutions; American Chemical Society; Analytical Chemistry; 84; 18; 9-2012; 7670-7676
dc.identifier.issn
0003-2700
dc.identifier.uri
http://hdl.handle.net/11336/61960
dc.description.abstract
Propofol is a widely used, potent intravenous anesthetic for ambulatory anesthesia and long-term sedation. The target steady state concentration of propofol in blood is 0.25-10 μg/mL (1-60 μM). Although propofol can be oxidized electrochemically, monitoring its concentration in biological matrixes is very challenging due to (i) low therapeutic concentration, (ii) high concentrations of easily oxidizable interfering compounds in the sample, and (iii) fouling of the working electrode. In this work we report the performance characteristics of an organic film coated glassy carbon (GC) electrode for continuous monitoring of propofol. The organic film (a plasticized PVC membrane) improved the detection limit and the selectivity of the voltammetric sensor due to the large difference in hydrophobicity between the analyte (propofol) and interfering compounds of the sample, e.g., ascorbic acid (AA) or p-acetamidophenol (APAP). Furthermore, the membrane coating prevented electrode fouling and served as a protective barrier against electrode passivation by proteins. Studies revealed that sensitivity and selectivity of the voltammetric method is greatly influenced by the composition of the PVC membrane. The detection limit of the membrane-coated sensor for propofol in PBS is reported as 0.03 ± 0.01 μM. In serum-like electrolyte solutions containing physiologically relevant levels of albumin (5%) and 3 mM AA and 1 mM APAP as interfering agents, the detection limit was 0.5 ± 0.4 μM. Both values are below the target concentrations used clinically during anesthesia or sedation. © 2012 American Chemical Society.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Propofol
dc.subject
Membrane-Coated Sensor
dc.subject
Passivation
dc.subject
Voltammetry
dc.subject.classification
Otras Ciencias Químicas
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Toward feedback-controlled anesthesia: Voltammetric measurement of propofol (2,6-diisopropylphenol) in serum-like electrolyte solutions
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-09-18T16:14:57Z
dc.journal.volume
84
dc.journal.number
18
dc.journal.pagination
7670-7676
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Washington
dc.description.fil
Fil: Kivlehan, Francine. University of Memphis; Estados Unidos
dc.description.fil
Fil: Garay, Fernando Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
dc.description.fil
Fil: Guo, Jidong. University of Memphis; Estados Unidos
dc.description.fil
Fil: Chaum, Edward. University of Tennessee; Estados Unidos
dc.description.fil
Fil: Lindner, Ernö. University of Memphis; Estados Unidos
dc.journal.title
Analytical Chemistry
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1021/ac3006878
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/abs/10.1021/ac3006878
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