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dc.contributor.author
Swinstead, Erin E.
dc.contributor.author
Paakinaho, Ville
dc.contributor.author
Presman, Diego Martin
dc.contributor.author
Hager, Gordon L.
dc.date.available
2018-10-01T17:55:20Z
dc.date.issued
2016-11
dc.identifier.citation
Swinstead, Erin E.; Paakinaho, Ville; Presman, Diego Martin; Hager, Gordon L.; Pioneer factors and ATP-dependent chromatin remodeling factors interact dynamically: A new perspective: Multiple transcription factors can effect chromatin pioneer functions through dynamic interactions with ATP-dependent chromatin remodeling factors; John Wiley & Sons Inc; Bioessays; 38; 11; 11-2016; 1150-1157
dc.identifier.issn
0265-9247
dc.identifier.uri
http://hdl.handle.net/11336/61392
dc.description.abstract
Transcription factor (TF) signaling regulates gene transcription and requires a complex network of proteins. This network includes co-activators, co-repressors, multiple TFs, histone-modifying complexes, and the basal transcription machinery. It has been widely appreciated that pioneer factors, such as FoxA1 and GATA1, play an important role in opening closed chromatin regions, thereby allowing binding of a secondary factor. In this review we will focus on a newly proposed model wherein multiple TFs, such as steroid receptors (SRs), can function in a pioneering role. This model, termed dynamic assisted loading, integrates data from widely divergent methodologies, including genome wide ChIP-Seq, digital genomic footprinting, DHS-Seq, live cell protein dynamics, and biochemical studies of ATP-dependent remodeling complexes, to present a real time view of TF chromatin interactions. Under this view, many TFs can act as initiating factors for chromatin landscape programming. Furthermore, enhancer and promoter states are more accurately described as energy-dependent, non-equilibrium steady states.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
John Wiley & Sons Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Chromatin Binding
dc.subject
Dynamic Assisted Loading
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Estrogen Receptor
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Foxa1
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Glucocorticoid Receptor
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Pioneer Factors
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Residence Time
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Pioneer factors and ATP-dependent chromatin remodeling factors interact dynamically: A new perspective: Multiple transcription factors can effect chromatin pioneer functions through dynamic interactions with ATP-dependent chromatin remodeling factors
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-10-01T16:10:46Z
dc.journal.volume
38
dc.journal.number
11
dc.journal.pagination
1150-1157
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Swinstead, Erin E.. National Cancer Institute; Estados Unidos
dc.description.fil
Fil: Paakinaho, Ville. National Cancer Institute; Estados Unidos
dc.description.fil
Fil: Presman, Diego Martin. National Cancer Institute; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Hager, Gordon L.. National Cancer Institute; Estados Unidos
dc.journal.title
Bioessays
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/bies.201600137
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/bies.201600137
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