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dc.contributor.author
Agiostratidou, Georgia
dc.contributor.author
Li, Maomi
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Suyama, Kimita
dc.contributor.author
Badano, Ines
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Keren, Rinat
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Chung, Su
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Anzovino, Amy
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Hulit, James
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Qian, Binzhi
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Bouzahzah, Boumediene
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Eugenin, Eliseo
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Loudig, Olivier
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Phillips, Greg R.
dc.contributor.author
Locker, Joseph
dc.contributor.author
Hazan, Rachel B.
dc.date.available
2018-09-20T19:41:45Z
dc.date.issued
2009-06
dc.identifier.citation
Agiostratidou, Georgia; Li, Maomi; Suyama, Kimita; Badano, Ines; Keren, Rinat; et al.; Loss of retinal cadherin facilitates mammary tumor progression and metastasis; American Association for Cancer Research; Cancer Research; 69; 12; 6-2009; 5030-5038
dc.identifier.issn
0008-5472
dc.identifier.uri
http://hdl.handle.net/11336/60510
dc.description.abstract
The mammary epithelium is thought to be stabilized by cellcell adhesion mediated mainly by E-cadherin (E-cad). Here, we show that another cadherin, retinal cadherin (R-cad), is critical for maintenance of the epithelial phenotype. R-cad is expressed in nontransformed mammary epithelium but absent from tumorigenic cell lines. In vivo, R-cad was prominently expressed in the epithelium of both ducts and lobules. In human breast cancer, R-cad was down-regulated with tumor progression, with high expression in ductal carcinoma in situ and reduced expression in invasive duct carcinomas. By comparison, E-cad expression persisted in invasive breast tumors and cell lines where R-cad was lost. Consistent with these findings, R-cad knockdown in normal mammary epithelium stimulated invasiveness and disrupted formation of acini despite continued E-cad expression. Conversely, R-cad overexpression in aggressive cell lines induced glandular morphogenesis and inhibited invasiveness, tumor formation, and lung colonization. R-cad also suppressed the matrix metalloproteinase 1 (MMP1), MMP2, and cyclooxygenase 2 gene expression associated with pulmonary metastasis. The data suggest that R-cad is an adhesion molecule of the mammary epithelium, which acts as a critical regulator of the normal phenotype. As a result, R-cad loss contributes to epithelial suppression and metastatic progression. ©2009 American Association for Cancer Research.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Association for Cancer Research
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
R-Cadherin
dc.subject
Cancer
dc.subject
Metastasis
dc.subject.classification
Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Loss of retinal cadherin facilitates mammary tumor progression and metastasis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-09-18T14:06:11Z
dc.journal.volume
69
dc.journal.number
12
dc.journal.pagination
5030-5038
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Philadelphia
dc.description.fil
Fil: Agiostratidou, Georgia. Albert Einstein College of Medicine, NY; Estados Unidos
dc.description.fil
Fil: Li, Maomi. Albert Einstein College of Medicine, NY; Estados Unidos. Montefiore Medical Center, NY; Estados Unidos
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Fil: Suyama, Kimita. Albert Einstein College of Medicine, NY; Estados Unidos
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Fil: Badano, Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Laboratorio de Biología Molecular Aplicada; Argentina. Albert Einstein College of Medicine, NY; Estados Unidos
dc.description.fil
Fil: Keren, Rinat. Albert Einstein College of Medicine, NY; Estados Unidos
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Fil: Chung, Su. Albert Einstein College of Medicine, NY; Estados Unidos
dc.description.fil
Fil: Anzovino, Amy. Albert Einstein College of Medicine, NY; Estados Unidos
dc.description.fil
Fil: Hulit, James. Albert Einstein College of Medicine, NY; Estados Unidos
dc.description.fil
Fil: Qian, Binzhi. Albert Einstein College of Medicine, NY; Estados Unidos
dc.description.fil
Fil: Bouzahzah, Boumediene. Albert Einstein College of Medicine, NY; Estados Unidos
dc.description.fil
Fil: Eugenin, Eliseo. Albert Einstein College of Medicine, NY; Estados Unidos
dc.description.fil
Fil: Loudig, Olivier. Albert Einstein College of Medicine, NY; Estados Unidos
dc.description.fil
Fil: Phillips, Greg R.. Mount Sinai School of Medicine, NY; Estados Unidos
dc.description.fil
Fil: Locker, Joseph. Albert Einstein College of Medicine, NY; Estados Unidos
dc.description.fil
Fil: Hazan, Rachel B.. Albert Einstein College of Medicine, NY; Estados Unidos
dc.journal.title
Cancer Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1158/0008-5472.CAN-08-4007
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://cancerres.aacrjournals.org/content/69/12/5030
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