Repositorio Institucional
Repositorio Institucional
CONICET Digital
  • Inicio
  • EXPLORAR
    • AUTORES
    • DISCIPLINAS
    • COMUNIDADES
  • Estadísticas
  • Novedades
    • Noticias
    • Boletines
  • Ayuda
    • General
    • Datos de investigación
  • Acerca de
    • CONICET Digital
    • Equipo
    • Red Federal
  • Contacto
JavaScript is disabled for your browser. Some features of this site may not work without it.
  • INFORMACIÓN GENERAL
  • RESUMEN
  • ESTADISTICAS
 
Artículo

Loss of retinal cadherin facilitates mammary tumor progression and metastasis

Agiostratidou, Georgia; Li, Maomi; Suyama, Kimita; Badano, InesIcon ; Keren, Rinat; Chung, Su; Anzovino, Amy; Hulit, James; Qian, Binzhi; Bouzahzah, Boumediene; Eugenin, Eliseo; Loudig, Olivier; Phillips, Greg R.; Locker, Joseph; Hazan, Rachel B.
Fecha de publicación: 06/2009
Editorial: American Association for Cancer Research
Revista: Cancer Research
ISSN: 0008-5472
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Inmunología

Resumen

The mammary epithelium is thought to be stabilized by cellcell adhesion mediated mainly by E-cadherin (E-cad). Here, we show that another cadherin, retinal cadherin (R-cad), is critical for maintenance of the epithelial phenotype. R-cad is expressed in nontransformed mammary epithelium but absent from tumorigenic cell lines. In vivo, R-cad was prominently expressed in the epithelium of both ducts and lobules. In human breast cancer, R-cad was down-regulated with tumor progression, with high expression in ductal carcinoma in situ and reduced expression in invasive duct carcinomas. By comparison, E-cad expression persisted in invasive breast tumors and cell lines where R-cad was lost. Consistent with these findings, R-cad knockdown in normal mammary epithelium stimulated invasiveness and disrupted formation of acini despite continued E-cad expression. Conversely, R-cad overexpression in aggressive cell lines induced glandular morphogenesis and inhibited invasiveness, tumor formation, and lung colonization. R-cad also suppressed the matrix metalloproteinase 1 (MMP1), MMP2, and cyclooxygenase 2 gene expression associated with pulmonary metastasis. The data suggest that R-cad is an adhesion molecule of the mammary epithelium, which acts as a critical regulator of the normal phenotype. As a result, R-cad loss contributes to epithelial suppression and metastatic progression. ©2009 American Association for Cancer Research.
Palabras clave: R-Cadherin , Cancer , Metastasis
Ver el registro completo
 
Archivos asociados
Tamaño: 7.167Mb
Formato: PDF
.
Solicitar
Licencia
info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/60510
DOI: http://dx.doi.org/10.1158/0008-5472.CAN-08-4007
URL: http://cancerres.aacrjournals.org/content/69/12/5030
Colecciones
Articulos(CCT - NORDESTE) [1916]
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - NORDESTE
Citación
Agiostratidou, Georgia; Li, Maomi; Suyama, Kimita; Badano, Ines; Keren, Rinat; et al.; Loss of retinal cadherin facilitates mammary tumor progression and metastasis; American Association for Cancer Research; Cancer Research; 69; 12; 6-2009; 5030-5038
Compartir
Altmétricas
 
Estadísticas
Visualizaciones: 105
Descargas: 0

Enviar por e-mail
Separar cada destinatario (hasta 5) con punto y coma.
  • Facebook
  • Twitter
  • Instagram
  • YouTube
  • Sound Cloud

Los contenidos del CONICET están licenciados bajo Creative Commons Reconocimiento 2.5 Argentina License

Ministerio
https://www.conicet.gov.ar/ - CONICET

Inicio

Explorar

  • Autores
  • Disciplinas
  • Comunidades

Estadísticas

Novedades

  • Noticias
  • Boletines

Ayuda

Acerca de

  • CONICET Digital
  • Equipo
  • Red Federal

Contacto

Godoy Cruz 2290 (C1425FQB) CABA – República Argentina – Tel: +5411 4899-5400 repositorio@conicet.gov.ar
TÉRMINOS Y CONDICIONES