Artículo
Synthesis of optically active 1,2,3-trisubstituted azetidines employing an organocatalytic approach with L-proline
Fecha de publicación:
30/01/2013
Editorial:
Elsevier
Revista:
Tetrahedron Letters
ISSN:
0040-4039
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
A concise organocatalytic approach towards optically active 1,2,3-trisubstituted azetidines, including a study of the scope and limitations of the synthetic sequence, is reported. The synthesis comprises the one-pot L-proline promoted three-component reaction between substituted benzaldehydes, anilines and enolizable aldehydes, followed by the in situ reduction of the resulting b-aminoaldehydes to the corresponding c-aminoalcohols and final intramolecular cyclization of the latter by way of the intermediate tosylates, formed in situ.
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Articulos(IQUIR)
Articulos de INST.DE QUIMICA ROSARIO
Articulos de INST.DE QUIMICA ROSARIO
Citación
Kaufman, Teodoro Saul; Amongero, Marcela; Synthesis of optically active 1,2,3-trisubstituted azetidines employing an organocatalytic approach with L-proline; Elsevier; Tetrahedron Letters; 54; 15; 30-1-2013; 1924-1927
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