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dc.contributor.author
Ámon, Judit
dc.contributor.author
Fernández y Martín, Rafael
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dc.contributor.author
Bokor, Eszter
dc.contributor.author
Cultrone, Antonietta
dc.contributor.author
Kelly, Joan M.
dc.contributor.author
Flipphi, Michel
dc.contributor.author
Scazzocchio, Claudio
dc.contributor.author
Hamari, Zsuzsanna
dc.date.available
2018-09-12T14:22:59Z
dc.date.issued
2017-12
dc.identifier.citation
Ámon, Judit; Fernández y Martín, Rafael; Bokor, Eszter; Cultrone, Antonietta; Kelly, Joan M.; et al.; A eukaryotic nicotinate-inducible gene cluster: Convergent evolution in fungi and bacteria; Royal Society Publishing; Open Biology; 7; 12; 12-2017; 1-17
dc.identifier.issn
2046-2441
dc.identifier.uri
http://hdl.handle.net/11336/59259
dc.description.abstract
Nicotinate degradation has hitherto been elucidated only in bacteria. In the ascomycete Aspergillus nidulans, six loci, hxnS/AN9178 encoding the molybdenum cofactor-containing nicotinate hydroxylase, AN11197 encoding a Cys2/His2 zinc finger regulator HxnR, together with AN11196/hxnZ, AN11188/hxnY, AN11189/hxnP and AN9177/hxnT, are clustered and stringently co-induced by a nicotinate derivative and subject to nitrogen metabolite repression mediated by the GATA factor AreA. These genes are strictly co-regulated by HxnR. Within the hxnR gene, constitutive mutations map in two discrete regions. Aspergillus nidulans is capable of using nicotinate and its oxidation products 6-hydroxynicotinic acid and 2,5-dihydroxypyridine as sole nitrogen sources in an HxnR-dependent way. HxnS is highly similar to HxA, the canonical xanthine dehydrogenase (XDH), and has originated by gene duplication, preceding the origin of the Pezizomycotina. This cluster is conserved with some variations throughout the Aspergillaceae. Our results imply that a fungal pathway has arisen independently from bacterial ones. Significantly, the neo-functionalization of XDH into nicotinate hydroxylase has occurred independently from analogous events in bacteria. This work describes for the first time a gene cluster involved in nicotinate catabolism in a eukaryote and has relevance for the formation and evolution of co-regulated primary metabolic gene clusters and the microbial degradation of N-heterocyclic compounds.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Royal Society Publishing
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Convergent Evolution
dc.subject
Cys2his2 Transcription Factor
dc.subject
Nicotinate Catabolic Gene Cluster
dc.subject
Nicotinate Hydroxylase
dc.subject
Xanthine Dehydrogenase
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
A eukaryotic nicotinate-inducible gene cluster: Convergent evolution in fungi and bacteria
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-09-11T14:46:44Z
dc.journal.volume
7
dc.journal.number
12
dc.journal.pagination
1-17
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Ámon, Judit. University of Szeged. Faculty of Science and Informatics; Hungría
dc.description.fil
Fil: Fernández y Martín, Rafael. Université Paris Sud; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Bokor, Eszter. University of Szeged. Faculty of Science and Informatics; Hungría
dc.description.fil
Fil: Cultrone, Antonietta. Université Paris Sud; Francia
dc.description.fil
Fil: Kelly, Joan M.. University of Essex; Reino Unido
dc.description.fil
Fil: Flipphi, Michel. Université Paris Sud; Francia
dc.description.fil
Fil: Scazzocchio, Claudio. Université Paris Sud; Francia. University of Essex; Reino Unido. Imperial College London; Reino Unido
dc.description.fil
Fil: Hamari, Zsuzsanna. Université Paris Sud; Francia. University of Szeged. Faculty of Science and Informatics; Hungría
dc.journal.title
Open Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1098/rsob.170199
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://rsob.royalsocietypublishing.org/content/7/12/170199
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746545/
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