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dc.contributor.author
Garro, Hugo Alejandro  
dc.contributor.author
García, Celina  
dc.contributor.author
Martin, Víctor S.  
dc.contributor.author
Pungitore, Carlos Rodolfo  
dc.contributor.author
Tonn, Carlos Eugenio  
dc.date.available
2016-05-27T19:26:59Z  
dc.date.issued
2014-08  
dc.identifier.citation
Garro, Hugo Alejandro; García, Celina; Martin, Víctor S.; Pungitore, Carlos Rodolfo; Tonn, Carlos Eugenio; Chemistry and Biological Activity of Coumarins at Molecular Level; Natural Products; Natural Product Communications; 9; 8; 8-2014; 1091-1094  
dc.identifier.issn
1934-578X  
dc.identifier.uri
http://hdl.handle.net/11336/5886  
dc.description.abstract
Synthetic coumarins were prepared using ionic liquids as an environmental friendly alternative with high yields. The compounds 3,4-dimethyl-7-hydroxycoumarin (3ab) and 3-isopropyl-4-methyl-5,7-dihydroxycoumarin (3bc) have showed interesting activity against Taq DNA polymerase with IC50 values of 115.74 μM and 82.24 μM, respectively. Also, the compounds 4-methyl-7-hydroxycoumarin (3aa) and 4-methyl-5,7-dihydroxycoumarin (3ba) have exhibited inhibitory activity against MMLV-RT with IC50 values of 23.46 μM and 18.35 μM, respectively. These inhibitors could have importance as antiretroviral chemotherapeutic agents and also in the development of antitumor drugs.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Natural Products  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/  
dc.subject
Coumarins  
dc.subject
Molecular Target  
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Antitumoral  
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Antiretroviral  
dc.subject.classification
Química Orgánica  
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Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Chemistry and Biological Activity of Coumarins at Molecular Level  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2016-05-16T20:06:19Z  
dc.journal.volume
9  
dc.journal.number
8  
dc.journal.pagination
1091-1094  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Westerville  
dc.description.fil
Fil: Garro, Hugo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; Argentina  
dc.description.fil
Fil: García, Celina. Universidad de la Laguna; España  
dc.description.fil
Fil: Martin, Víctor S.. Universidad de la Laguna; España  
dc.description.fil
Fil: Pungitore, Carlos Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; Argentina  
dc.description.fil
Fil: Tonn, Carlos Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; Argentina  
dc.journal.title
Natural Product Communications  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/abs/10.1177/1934578X1400900808  

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