Artículo

Chemistry and Biological Activity of Coumarins at Molecular Level

Garro, Hugo AlejandroIcon ; García, Celina; Martin, Víctor S.; Pungitore, Carlos RodolfoIcon ; Tonn, Carlos EugenioIcon
Fecha de publicación: 08/2014
Editorial: Natural Products
Revista: Natural Product Communications
ISSN: 1934-578X
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

Synthetic coumarins were prepared using ionic liquids as an environmental friendly alternative with high yields. The compounds 3,4-dimethyl-7-hydroxycoumarin (3ab) and 3-isopropyl-4-methyl-5,7-dihydroxycoumarin (3bc) have showed interesting activity against Taq DNA polymerase with IC50 values of 115.74 μM and 82.24 μM, respectively. Also, the compounds 4-methyl-7-hydroxycoumarin (3aa) and 4-methyl-5,7-dihydroxycoumarin (3ba) have exhibited inhibitory activity against MMLV-RT with IC50 values of 23.46 μM and 18.35 μM, respectively. These inhibitors could have importance as antiretroviral chemotherapeutic agents and also in the development of antitumor drugs.
Palabras clave: Coumarins , Molecular Target , Antitumoral , Antiretroviral
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial 2.5 Unported (CC BY-NC 2.5)
Identificadores
URI: http://hdl.handle.net/11336/5886
URL: https://journals.sagepub.com/doi/abs/10.1177/1934578X1400900808
Colecciones
Articulos(INTEQUI)
Articulos de INST. DE INVEST. EN TECNOLOGIA QUIMICA
Citación
Garro, Hugo Alejandro; García, Celina; Martin, Víctor S.; Pungitore, Carlos Rodolfo; Tonn, Carlos Eugenio; Chemistry and Biological Activity of Coumarins at Molecular Level; Natural Products; Natural Product Communications; 9; 8; 8-2014; 1091-1094
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